用计算机模型研究葡激酶与人微小纤溶酶原的相互作用  

Studies on the Interaction Between Staphylokinase and Microplasminogen Based on Computer Model

作　　者：宋钢[1] 宋后燕[1] 茅翔[2] 

机构地区：[1]上海医科大学分子遗传学研究室 [2]中国科学院上海植物生理研究所

出　　处：《高技术通讯》1999年第4期48-51,共4页Chinese High Technology Letters

基　　金：863计划资助项目

摘　　要：利用计算机同源模建预测人微小纤溶酶原的三维结构，与葡激酶Ｘ射线晶体结构进行了分子对接，研究了葡激酶与微小溶酶原的结合区，并设计了分子量小、低抗原性的新型葡激酶分子。The 3 D structure of human microplasminogen was predicted by the method of homology modeling. The binding sites of staphylokinase and micropasminogen were determined by high resolution generic docking. This model is consistent with several known experimental properties of staphylokinase. Novel variants of staphylokinase were designed with reducing immunogenecity, low molecular weight and with intact thrombolytic potencies.

关 键 词：葡激酶 微小纤溶酶原 分子设计 计算机模型 

分 类 号：Q556.01[生物学—生物化学]