HBV感染患者不同免疫状态下血清sICAM-1表达的研究  

Study on the expression of sICAM-1 in the sera of patients with HBV infection during different immune status

作　　者：杨丽莎[1] 王钊[1] 覃理灵[1] 何武[1] 周劲刚[1] 吴淋玲[1] 黄亚琴[1] 

机构地区：[1]桂林医学院附属医院中西医结合科,541001

出　　处：《重庆医学》2010年第23期3158-3159,共2页Chongqing medicine

基　　金：国家自然科学基金资助项目(30760294)

摘　　要：目的探讨可溶性细胞间黏附分子-1(sICAM-1)在乙型肝炎病毒(HBV)感染不同免疫状态患者血清中的表达及其意义。方法选择HBV感染患者按不同免疫状态分成免疫耐受组(80例)、免疫清除组(80例)、免疫不全组(80例,分成免疫不全A、B组,各40例);并选40名非HBV感染健康体检者作为对照组,利用ELISA法对HBV感染不同免疫状态三组及对照组血清sICAM-1水平进行测定。结果免疫清除、免疫不全B组sICAM-1水平较对照组有不同程度的升高,差异有统计学意义(P<0.05);免疫耐受、免疫不全A组与对照组比较,差异无统计学意义(P>0.05)。结论血清sICAM-1变化对于判断HBV感染不同免疫状态肝脏组织病情变化有一定的临床价值。Objective To study the expression and significance of the serum levels of soluble intercellular adhesion molecule-1（sICAM-1）in patients with different immune status of Hepatitis B Virus（HBV） infection.Methods Grouping the patients of HBV infection into five teams,with immune tolerance,immune clearance,Immunodeficiency（A）,Immunodeficiency（B）.Serum samples were collected from 80 cases of immune tolerance,80 cases of immune clearance,40 cases of Immunodeficiency（A）,40cases of Immunodeficiency（B）and 40cases of normal control.Serum levels of sICAM-1 were measured by Enzyme-linked immunosorbent assay（ELISA）.Results Serum levels of sICAM-1 in patients with immune clearance and Immunodeficiency（B）,compared with normal control（P〈0.05）;Serum levels of sICAM-1 in patients with immune tolerance,Immunodeficiency（A）were not significantly different,compared with normal control（P〈0.05）.Conclusion Serum levels of sICAM-1 may reflect the disease progressed in patients with different immune status of HBV and have certainly valuable for clinical significance.

关 键 词：HBV感染 不同免疫状态 可溶性细胞间黏附分子-1 

分 类 号：R512.62[医药卫生—内科学] R446.61[医药卫生—临床医学]