针刺对高脂血症大鼠血脂及血清一氧化氮含量和髓过氧化物酶活力的影响  

Effect of acupuncture on NO contents of serum and activity of myeloperoxidase in rat with hyperlipoidemia

作　　者：蔡辉[1] 袁爱红[1] 

机构地区：[1]中国人民解放军南京军区南京总医院中西医结合科,江苏南京210002

出　　处：《河北中医》2010年第9期1404-1406,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：2009年江苏省博士后科研资助项目(编号:0901066C)

摘　　要：目的观察针刺对高脂血症大鼠血脂及一氧化氮(NO)含量和髓过氧化物酶(MPO)活力的影响。方法 将26只SD大鼠随机分为模型组8只,治疗组和正常组各9只。正常组予普通饲料,模型组和针刺组均予高脂饲料。喂养16周后治疗组施以针刺疗法,每日1次,6 d为1个疗程,疗程间隔1 d,连续治疗4个疗程;模型组和正常组均未给予治疗措施。针刺干预4个疗程后测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、NO的含量及MPO活力。结果模型组TG、TC及LDL-C含量均显著高于正常组(P<0.01或P<0.05);治疗组TG、TC及LDL-C含量均显著低于模型组(P<0.01或P<0.05);模型组NO含量显著低于正常组(P<0.01),治疗组NO含量显著高于模型组(P<0.05);模型组血清MPO活力明显高于正常组和治疗组(P<0.01)。结论高脂饮食能够增加机体的氧化应激状态,针刺能够降低血脂,其机制可能与抑制机体氧化应激状态有关。Objective To observe the effect of acupuncture on NO contents of serum and activity of myeloperoxidase in rat with hyperlipoidemia.Methods 26 SD rats were randomly divided into model group（n=8）,treatment group（n=9） and control group（n=9）.Rats in control group were fed by normal feeds.Rat in treatment group and model group were fed by high fat feeds.After 16 weeks of feed only rats in treatment group were treated by acupuncture,once a day for six days.Interval of course was one day.After four courses TG,TC,HDL-C,LDL-C,NO and activity of MPO were measured.Results TG,TC,HDL-C and LDL-C in model group were higher than those in control group（P〈0.01,P〈0.05）.TG,TC AND LDL-C in treatment group were higher than those in model group（P〈0.01,P〈0.05）.NO content in treatment group was higher than that in model group（P〈0.05）.Conclusion High fat diet can increase oxidative stress state of organism.Acupuncture can decrease blood lipid,the mechanism may be related to suppress oxidative stress state of organism.

关 键 词：一氧化氮 动脉粥样硬化 针刺疗法 脂类 疾病 动物模型 

分 类 号：R245.311[医药卫生—针灸推拿学] R-332[医药卫生—中医临床基础]