土霉素在鸡体内的生理房室模型研究  

Physiological Compartment Model of Oxytetracycline in Chicken

作　　者：鲍杰[1] 罗显阳[2] 朱理想[2] 王蕊[2] 远立国[2] 

机构地区：[1]北京市动物卫生监督所,北京100044 [2]华南农业大学兽医学院,广东广州510642

出　　处：《中国家禽》2010年第22期25-27,共3页China Poultry

基　　金：中国博士后科学基金(20080440762)

摘　　要：为预测土霉素在鸡体内的药动学特点,建立了土霉素在鸡体内的血流限速生理房室模型。结果显示,土霉素在鸡体内的药动学参数:Tmax(达峰时间)为2.22h,Cmax(峰浓度)为0.62μg/mL,AUC(药时曲线下面积)为7.61(μg/mL)×h,Ka(吸收速率常数)为1.21h-1,Ke(消除速率常数)为0.10h-1,T1/2Ka(吸收半衰期)为0.57h,T1/2Ke(消除半衰期)为6.73h,V(表观分布容积)为6.38L/kg,CL(血浆清除率)为0.66L/h·kg。其结果表明,土霉素在鸡体内的药动学特点为:吸收迅速,分布广泛,消除缓慢。因此,运用生理房室模型可以预测药物的药动学参数。To predict the pharmacokinetic charac, teristics of Oxytetracycline in chicken,a flow limited physiological compartment model for Oxytetracycline in chicken was developed. The pharmacokinetic parameters of Oxytetraeycline in chicken were as follows ： Tmax 2.22 h,Cmax 0.62 μg/mL,AUC 7.61（μg/mL）×h,K, 1.21 h^-1,Ke 0.10 h^-1,T1/2Ka 0.57 h,T1/2Ke 6.73 h, V 6.38 L/kg,CL 0.66 L/h·kg. The results indicated that the pharmacokinetic characteristics were absorbed rapidly, distributed widely and eliminated slowly. The drug pharmacokinetic parameters can be predicted by the physiological compartment model.

关 键 词：土霉素 生理房室模型 鸡 药动学参数 

分 类 号：O175.1[理学—数学]