儿童急性白血病医院获得性肺炎临床分析  

Hospital-acquired Pneumonia in Children with Acute Leukemia:A Clinical Analysis

作　　者：钱江潮[1] 方希敏[1] 周海霞[1] 王菊香[1] 李原[1] 

机构地区：[1]温州医学院附属第二医院儿童血液肿瘤科,浙江温州325027

出　　处：《中华医院感染学杂志》2010年第23期3682-3683,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨急性白血病患儿中性粒细胞缺乏期发生医院获得性肺炎的临床特点,为临床早期诊断、准确治疗提供依据。方法对2006年1月-2009年1月收治的144例急性白血病患儿接受强化疗后致中性粒细胞缺乏,发生医院获得性肺炎28例进行分析总结。结果急性白血病患儿医院获得性肺炎发病率19.4%,中性粒细胞数下降是医院获得性肺炎的主要危险因素,常规行肺部CT可早期诊断医院获得性肺炎,美罗培南、头孢哌酮/舒巴坦治疗医院获得性肺炎效果显著。结论加强支持治疗是预防和治疗急性白血病患儿医院获得性肺炎的重要措施。OBJECTIVE To analyze the characteristic of hospital-acquired pneumonia（HAP） in children patients with acute leukemia during the neutropenia stage,to explore the strategy of early diagnosis and treatment.METHODS Totally 144 cases of children patients with acute leukemia from Jan 2006 to Jan 2009 were involved in the retrospective review.The patients with acute leukemia and HAP were selected out in accordance with diagnostic criteria of HAP.Clinical characteristics and pathogens of infection were analyzed.RESULTS The incidence of HAP in children patients with acute leukemia during the neutropenia stage was 19.4%.Decreased neutrophil was the major risk factor in HAP.The routine serial chest CT could be used for the early diagnosis of HAP.Meropenem and cefoperazone/sulbactam used to treat HAP had better efficiency.CONCLUSION Enhancing prevention and treatment of children with HAP is important.

关 键 词：急性白血病 儿童 医院获得性肺炎 临床分析 

分 类 号：R181.32[医药卫生—流行病学]