补肾活血法、补肾法和活血法对AD患者认知功能及AD模型大鼠行为学的影响  

The Effect of Invigorate the Kidney and Promoting Blood Flow Therapy,Invigorate the Kidney Therapy and Promoting Blood Flow Therapy on Cognition Function in Patients and Ethology in Rats with Alzheimer's Disease

作　　者：周锋[1] 朱宏[1] 董克礼[1] 

机构地区：[1]中南大学湘雅三医院,410013

出　　处：《湖南中医杂志》2010年第6期1-4,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省自然科学基金资助项目(07JJ5017);湖南省中医药管理局科研基金资助项目(2009066)

摘　　要：目的:观察补肾活血法、补肾法和活血法治疗AD患者疗效及对痴呆模型大鼠行为学的影响。方法:临床观察随机分为3组(补肾活血组、补肾组、活血组),分别予以中药治疗12周,治疗前后分别进行MMSE、ADL评分;动物实验将36只SD大鼠随机分为6组(正常组、假手术组、模型组、补肾活血组、补肾组、活血组),分别予以不同方法干预后进行水迷宫试验。结果:临床观察补肾活血组认知功能改善明显优于补肾组和活血组(P<0.05),补肾组与活血组比较差异无统计学意义(P>0.05);动物实验部分:3组中药治疗组潜伏期较模型组明显缩短,跨越平台次数显著增加(P<0.01),与正常组和假手术组之间比较无显著差异(P>0.05),补肾活血组潜伏期较补肾组、活血组明显缩短,跨越平台次数显著增加(P<0.05)。结论:补肾活血法治疗AD的疗效均优于补肾法和活血法。Objective： To observe the clinical effect on invigorate the kidney and promoting blood flow therapy, invigorate the kidney therapy and promoting blood flow therapy on cognition function in patients and ethology in rats with alzheimer＇ s disease. Method： Cases were randomly divided into 3 groups （ invigorate the kidney and promoting blood flow therapy group, invigorate the kidney therapy group and promoting blood flow therapy group） and treated by Chinese medicinal materials separately for 12 weeks. MMSE and ADL were evaluated before and after treatment. 36 rats with alzheimer＇ s disease were randomly divided into 6 groups （normal group, sham operation group, model group, invigorate the kidney and promoting blood flow therapy group, invigorate the kidney therapy group and promoting blood flow therapy group） and carry out water maze test after intervention with different methods. Results： The clinical test： the improvement of cognition function in invigorate the kidney and promoting blood flow therapy group was superior to that in the invigorate the kidney therapy group and promoting blood flow therapy group（ P 〈 0.05 ） ,there was no statistically significant as compared between the invigorate kidney therapy group and promoting blood flow therapy group（ P 〉 0.05 ）. The animal experiment ： the delitescence was decurtated and frequency of spanning platform increased markedly in 3 Chinese medicine treatment groups（P 〈0.01 ）. There were no significant deviation as compared between normal group and sham operation group（ P 〉 0. 05 ）. The delitescenee was decurtated and frequency of spanning platform increased markedly in invigorate the kidney and promoting blood flow therapy group as compared with the invigorate kidney therapy group and promoting blood flow therapy group（ P 〈 0. 05 ）. Conclusion： The effect of invigorate the kidney and promoting blood flow therapy in treating alzheimer＇ s disease was superior to the invigorate kidney therapy and promoting blood flow

关 键 词：阿尔茨默病 中医药疗法 补肾活血法 

分 类 号：R259.565[医药卫生—中西医结合]