戒毒康对吗啡依赖豚鼠离体回肠戒断性收缩的影响  

Effect of Jiedukang on Morphine Dependence Withdrawal Contraction in Isolated Guinea Pig Ileum

作　　者：毛培江[1] 金祖汉[1] 金捷[1] 杨毅[1] 

机构地区：[1]浙江省中药研究所,杭州310023

出　　处：《中国现代应用药学》2010年第11期964-967,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省科技厅科研院所研究开发项目(2006F12035)

摘　　要：目的研究戒毒康对吗啡依赖豚鼠离体回肠催促戒断反应的抑制作用。方法连续递增皮下注射吗啡,建立豚鼠身体依赖性模型,利用MD2000 Super Lab生物信息采集系统观察戒毒康对纳洛酮催促诱发吗啡身体依赖性豚鼠离体回肠的戒断性收缩的抑制作用。结果戒毒康高(0.6 mg.mL-1)、中(0.3 mg.mL-1)、低(0.15 mg.mL-1)3个剂量对吗啡依赖豚鼠离体回肠纳洛酮催促戒断性收缩的抑制率分别为:78.8%,46.8%,30.0%,并呈剂量相关性,其中高剂量组和中剂量组与模型组比较,有显著性差异。结论戒毒康在一定程度上能抑制吗啡依赖豚鼠离体回肠体外纳洛酮催促戒断性收缩。OBJECTIVE To investigate the effects of Jiedukang on the morphine dependence withdrawal contraction in the isolated guenea pig ileum precipitated by naloxone. METHODS Morphine dependent model was established in isolated guinea pig ileum. With MD2000 Super Lab Bio-information acquisition system, observe the effects of different doses of Jiedukang on the withdrawal contraction in the isolated guenea pig ileum precipitated by naloxone. RESULTS Jiedukang （0.6, 0.3, 0.15 mg.mL？1） can inhibit morphine-dependent withdrawal contracture in isolated guinea pig ileum in a dose-dependant manner. The inhibition rate of three dosages were 78.8%, 46.8% and 30.0%, respectively. CONCLUSION Jiedukang can inhibit morphine-dependent withdrawal contracture in isolated guinea pig ileum.

关 键 词：戒毒康 身体依赖性 吗啡依赖 豚鼠离体回肠 戒断症状 

分 类 号：R965[医药卫生—药理学]