“非抗菌药物剂量和频次智能化监控系统”的研发  

The Effect of Developing "the Intelligent Prescription Screening System about Non-antimicrobial Agents’ Dosage and Dosing Interval"

作　　者：翟晓波[1] 严海东[2] 何志高[1] 鲍思蔚[2] 文传民 

机构地区：[1]同济大学附属东方医院药学部,上海200120 [2]同济大学附属东方医院肾脏内科,上海200120 [3]大通医药信息技术有限公司,上海201203

出　　处：《中国现代应用药学》2010年第11期1036-1043,共8页Chinese Journal of Modern Applied Pharmacy

基　　金：上海市卫生局科研课题(2009163);同济-国药医院管理研究基金(TJGY0803);上海市科委生物医药重点项目(08411951300)

摘　　要：目的研发"非抗菌药物剂量和频次智能化监控系统"以减少相关药物不良事件和提高疗效。方法基于医院信息系统,实现非抗菌药物使用剂量和频次与患者年龄、体重、体表面积、肾功能状况相链接。结果随机抽取1 d的数据,在1 382张住院患者的非抗菌药物处方中,"系统"共出现438条警示。对无需按年龄、肾功能等调整剂量和频次的药物,"系统"审查出单次剂量过大而频次适中警示172条,单次剂量过大而频次不足警示90条,单次剂量适中而频次不足警示61条,单次剂量适中而频次过多警示47条,单次剂量过小和频次适中或不足36条。而对需按年龄、肾功能等调整剂量和频次的药物,"系统"审查出剂量过大和(或)频次过多警示32条。结论这种链接方式切实可行,当非抗菌药物处方中出现不符合说明书规定的使用剂量和(或)频次时,能够被该"系统"识别,而其临床作用有待实践检验。OBJECTIVE To develop ＂the intelligent prescription screening system about the non-antimicrobial agents’ dosage and dosing interval＂ in order to decrease adverse drug events and increase therapeutic efficacy.METHODS Base on the information system of the hospital to realize the connection between the non-antimicrobial agents’ dosage and dosing interval with patients’ ages,weights,body surface areas and renal functions.RESULTS Pick out one day’s data randomly,including 1 382 prescriptions of the non-antimicrobial agents in hospitalized patients,the ＂system＂ examined and provided 438 warnings.There were 172 warnings of overdosage each time and moderate dosing interval,90 warnings of overdosage each time and inadequate dosing interval,61 warnings of moderate dosage each time and inadequate dosing interval,47 warnings of moderate dosage each time and excessive dosing interval,36 warnings of inadequate dosage each time and moderate or inadequate dosing interval in adults with normal renal functions.There were 32 warnings of overdosage and excessive dosing interval in drugs that should be adjusted according to patients’ ages and renal functions.CONCLUSION This kind of connection is practical.When prescriptions which violate the rules of dose and（or） dosing interval are present,they can be found out by the ＂system＂,but its effect on the clinical is to be proved.

关 键 词：非抗菌药物 剂量 频次 智能化 肌酐清除率 体表面积 

分 类 号：R954[医药卫生—药学]