生酮饮食在大鼠心肌缺血再灌注损伤中的保护作用  

Protective function of ketogenic diet（ KD ） on myocardial ischemia-reperfusion injury in rats

作　　者：安良香[1] 刘志强[2] 杨欣欣[2] 窦珊珊[2] 程丹富[1] 程葆华[2] 

机构地区：[1]日照市人民医院心电图室,山东省276826 [2]济宁医学院解剖教研室,山东省276826

出　　处：《中国心血管病研究》2010年第12期942-943,共2页Chinese Journal of Cardiovascular Research

摘　　要：目的 研究生酮饮食（KD）在大鼠心肌缺血再灌注损伤中的保护作用.方法 分别给予SD雄性大鼠正常饮食（ND）和KD 6周后,结扎大鼠冠状动脉左前降支30 min,恢复再灌注60 min,通过观察心电图和心肌酶学指标,评价KD对大鼠心肌缺血再灌注损伤的保护作用.结果 KD减轻了大鼠心肌缺血再灌注损伤引起的ST段抬高,降低了乳酸脱氢酶和肌酸激酶的水平.结论 KD对大鼠心肌缺血再灌注损伤具有保护作用.Objective To investigate protection of KD on myocardial ischemia-reperfusion injury in rats. Methods After pretreatment normal diet（ND） and KD respectively in male rats for 6 weeks all the rats were ligated with the left anterior descending coronary arteries for 30 min and then reperfused for 60 rain. The protection of KD on myocardial ischemia-reperfusion injury was evaluated by ECG monitoring and CK measurement. Results KD alleviated the elevation of ST segment induced by myocardial ischemia-reperfusion injury and decreased the levels of LDH and CK. Conclusion KD was protective on myocardial ischemia-reperfusion injury in rats.

关 键 词：生酮饮食 缺血再灌注 正常饮食 心电图 

分 类 号：R542.2[医药卫生—心血管疾病] Q95-33[医药卫生—内科学]