功能化SBA-15-NH_2在药物布洛芬吸附与控制释放的研究  

Functionalized SBA-15 Materials as Carriers for Adsorption and Controlled Drug Delivery

作　　者：孙丽娜[1] 张晓彤[1] 陈雷[1] 张翻[1] 潘明雪[1] 宋丽娟[1] 

机构地区：[1]辽宁石油化工大学辽宁省石油化工重点实验室,辽宁抚顺113001

出　　处：《石油化工高等学校学报》2010年第3期1-5,共5页Journal of Petrochemical Universities

基　　金：国家自然基金资助项目(20976077)

摘　　要：采用合成后改性法将氨基嫁接进介孔SBA-15孔道内,对功能化的SBA-15进行药物吸附与控制释放研究。利用X射线衍射(XRD)、智能重量分析仪(IGA)、透射电镜(TEM)、红外光谱仪(IR)等表征手段对它的物理结构、化学组成进行表征,在此基础上,利用分子模拟软件对其空间骨架结构及与药物分子之间的相互作用进行模拟。对目标药物布洛芬(IBU)负载进改性前后的SBA-15材料内表面进行研究。结果表明,药物吸附和缓释性能与SBA-15材料内表面官能团有着密切的关系。由于药物IBU分子与功能化SBA-15-NH2内表面的氨基基团之间存在离子相互作用,故其药物释放时间比单纯的SBA-15更长。Mesoporous SBA-15 materials were functionalized with amine groups through postsynthesis, and resulting functionalized material was investigated as matrix for controlled drug delivery. The structure, composition and framework of the material were investigated by means of X-ray diffraction （XRD）, intelligent weight analyzer （IGA）, transmission scanning electron microscopy （TEM）, infrared spectrometer （IR）, and molecular simulation software. Ibuprofen （IBU） was selected as model drug and loaded onto the unmodified and functionalized SBA-15. It was revealed that the adsorption capacities and release behaviors of this model drug were highly dependent on the surface properties of SBA-15 materials. The release rate of IBU from SBA-15 functionalized by postsynthesis is found to be effectively controlled as compared to that from pure SBA-15 due to the ionic interaction between carboxyl groups in IBU and amine groups on the surface of SBA-15.

关 键 词：SBA-15 布洛芬 药物缓释 吸附 

分 类 号：TQ12[化学工程—无机化工]