抗癌药物铂络合物构效关系的物理方法研究  

THE STRUCTURE EFFECT RELATION OF PLATINUM ANTICANCER COMPLEXES BY PHYSICAL METHODS

作　　者：李乃英[1] 

机构地区：[1]陕西师范大学学报编辑部

出　　处：《光子学报》1999年第5期440-442,共3页Acta Photonica Sinica

基　　金：国家自然科学基金

摘　　要：本文用Ｘ射线衍射、傅里叶变换红外光谱、差热分析等物理方法研究了抗癌药物铂络合物特性、结构以及构效关系．研究结果表明：ｃｉｓ－［Ｐｔ（ＮＨ３）２Ｃｌ２］属简单斜方晶系，晶格常数ａ＝０．９２２１ｎｍ，ｂ＝０．８７７１ｎｍ，ｃ＝０．６８９０ｎｍ．草酸二氨合铂的结构为斜方晶系，其晶格常数为：ａ１＝１．０７２１ｎｍ，ａ２＝０．６４０２ｎｍ，ａ３＝１．８５７０ｎｍ，并用傅里叶变换红外光谱、差热分析。Employing X ray diffraction,Fourier transformation infrared spectrum and differential thermalanalysismethods,theproperties,structuresandstructure effectrelationofplatinumanticancer complexes are investigated in this paper.The current research results show that cis[Pt(NH 3) 2Cl 2]is a monoclinic lattice,the corresponding crystal constants read:a=0.9221nm,b=0.8771nm,c= 0.6890nm.The structure of oxalic platoammine is a triclinic lattice,the crystal constants are a 1= 1.0721nm,a 2=0.6402nm,a 3=1.8570nm.It′s chemical and physical properties are studied by the optical methods mentioned previously.

关 键 词：铂铬合物 X射线衍射 红外光谱 构效关系 抗癌药 

分 类 号：R979.1[医药卫生—药品]