通心络胶囊对代谢综合征患者血管内皮功能障碍的影响  

Influence of Tongxinluo Capsule on Vascular Endothelial Dysfunction in Patients with Metabolic Syndrome

作　　者：黄俊[1] 鲁爱粉[1] 万欢[1] 吴钧芳[1] 路军[1] 

机构地区：[1]南昌大学第一附属医院心血管内科,南昌330006

出　　处：《南昌大学学报（医学版）》2010年第9期36-39,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨通心络胶囊对代谢综合征(metabolic syndrome,MS)患者血管内皮功能障碍的影响。方法将86例MS患者按随机数字表法分为2组:治疗组44例和对照组42例。2组患者均采用常规治疗。在此基础上,治疗组加用通心络胶囊治疗。2组患者治疗前、治疗4周后分别检测空腹葡萄糖(FPG)、空腹胰岛素(FINS)、一氧化氮(NO)、内皮素(ET)、血脂[胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)]、血压[收缩压(SBP)、舒张压(DBP)]及肱动脉内皮依赖性血管舒张功能(EDF)。结果与治疗前比较,2组患者治疗4周后SBP、DBP、FPG、FINS、TC、TG、HDL-C、NO、ET、EDF均有明显改善(均P<0.01)。与对照组治疗4周后比较,治疗组患者NO、ET、EDF水平均有明显改善(均P<0.01),而TC、TG、HDL-C、FINS、FPG、SBP、DBP水平均无明显改善(均P>0.05)。结论 MS患者存在血管内皮功能障碍,通心络胶囊对MS患者的血管内皮功能障碍有保护作用。Objective To explore the influence of Tongxinluo capsule on vascular endothelial dysfunction in patients with metabolic syndrome（MS）.Methods Eighty-six patients with MS were randomly divided into two groups： treatment group（n=44） and control group（n=42）.All patients received conventional therapy.On this basis,the patients in treatment group were treated with Tongxinluo capsule.Fasting plasma glucose（FPG）,fasting insuline（FINS）,nitric oxide（NO）,endotheline（ET）,cholesterol（TC）,triglyceride（TG）,high-density lipoprotein（HDL-C）,systolic blood pressure（SBP）,diastolic blood pressure（DBP） and endothelium-dependent vasodilation（EDF） were detected before and after 4 weeks of treatment.Results Compared with pre-treatment,the levels of SBP,DBP,FPG,FINS,TC,TG,HDL-C,NO,ET and EDF were significantly improved in both groups after 4 weeks of treatment（all P〈0.01）.Compared with the control group,the levels of NO,ET and EDF in the treatment group were obviously improved（all P〈0.01）,but there were no significant differences in TC,TG,HDL-C,FINS,FPG,SBP and DBP between the two groups（all P〉0.05）.Conclusion Tongxinluo capsule has a protective effect on vascular endothelial dysfunction in patients with MS.

关 键 词：代谢综合征 通心络胶囊 血管内皮功能障碍 

分 类 号：R589[医药卫生—内分泌]