五味子藤茎中木脂素对四氯化碳致小鼠急性肝损伤的保护作用  

Protective effects of Lignans in caulis Schisandra Chinensis on acute liver injure of rats induced by CCl_4

作　　者：姚莹[1] 李昌煜[2] 林婷[2] 

机构地区：[1]浙江医学高等专科学校 [2]浙江中医药大学

出　　处：《中国临床药理学与治疗学》2010年第9期978-982,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省中医药科技计划项目(2008YA014)

摘　　要：目的:探讨五味子藤茎中木脂素对四氯化碳(CCl4)致小鼠急性肝损伤的保护作用。方法:采用CCl4致小鼠急性肝损伤模型,观察五味子藤茎中木脂素对小鼠血清ALT、AST活性及肝组织匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)水平的影响,同时观察肝组织病理学改变。结果:五味子藤茎中木脂素能明显降低血清ALT、AST水平,降低肝匀浆MDA的含量,提高SOD、GSH-Px活力,肝脏病理损伤有明显改善。高剂量组抗肝损伤作用与联苯双酯阳性对照组相当。结论:五味子藤茎中木脂素对CCl4致小鼠急性肝损伤具有一定的保护作用,其作用机制与其抗氧化作用有关。AIM：To approach the protective effects of lignans in caulis Schisandra Chinensis on acute liver injure in rats induced by CCl4. METHODS：By using the CCl4 induced acute liver injury rat model,the effects of lignans in caulis Schisandra Chinensis on the levels of ALT and AST in serum and the contents of SOD,MDA and GSH-Px in liver homogenate,and the pathological change of liver tissue were observed.RESULTS：The lignans in caulis Schisandra Chinensis decreased the levels of ALT and AST in serum,decreased the content of MDA in liver homogenate,and increased the activities of SOD and GSH-Px.The pathological injury of liver could be obviously improved.The effect of anti-injury on liver of high dosage group was equal to that of bifendate positive group.CONCLUSION：Caulis Schisandra Chinensis has protective effect on acute liver injury of rats induced by CCl4,and the mechanism is related to its antioxidant effect.

关 键 词：五味子藤茎 木脂素 四氯化碳 肝损伤 

分 类 号：R965.1[医药卫生—药理学]