不同水平的低密度脂蛋白胆固醇人群的动脉弹性  

Arterial elasticity in population with different levels of low density lipoprotein cholesterol

作　　者：陶红[1] 林江[1] 陈立新[1] 岑敏[1] 

机构地区：[1]暨南大学附属深圳市人民医院体检科,518020

出　　处：《中华生物医学工程杂志》2010年第3期249-251,共3页Chinese Journal of Biomedical Engineering

摘　　要：目的观察不同水平的低密度脂蛋白胆同醇（LDL—C）人群动脉弹性的变化。方法对象为2008年1月至2009年12月在本院体检中心体检者315例，平均年龄（51±11）岁，男性175例，女性140例。根据美国国家胆同醇教育计划（NCEP-Ⅲ）标准，按照血清LDL—C水平分为4组：LDL．C正常组（C组，n=88，LDL—C：2．63—3．41mmol／L）；LDL—C临界升高组（H1组，n=37，LDL—C：3．42～4．20mmol／L）；LDL—C升高组（H2组，n=69，LDL-C：4．21～4．97mmol／L）；LDL，C显著升高组（H3组，n=121，LDL—C≥4．98mmol／L）。应用动脉硬化测定仪检测各组体检者的脉搏波传导速度（PWV）和踝臂指数（AgI），并行组间比较。结果C组和H1组体检者的PWV值处于正常范围，H2组和H3组则轻度升高，与C组、H1组差异有统计学意义[H2组：（1623±115）cm／s，H3组：（1720±100）cm／s，C组：（1288±103）cm／s，H1组：（1266±112）cm／s，P〈0．05]。各组ABI值正常，差异无统计学意义。结论低密度脂蛋白胆同醇升高者早期动脉血管弹性下降，PWV检测有助于发现LDL—C升高的早期动脉粥样硬化。Objective To investigate the arterial elasticity change in population with different levels of low density lipoprotein cholesterol （LDL-C）. Methods A total of 315 persons, 175 males and 140 females, aged （51 ± 11 ） years old, who underwent physical examination in our hospital during January 2008 and December 2009, were classified into 4 groups according to the national cholesterol education program Ⅲ criteria： normal LDL-C group （C group, n=88, LDL-C： 2.63-3.41 retool/L） ; supercritical LDL-C group （H1 group, n=37, LDL-C： 3.42-4.20 retool/L） ; high LDL-C group （H2 group, n=69, LDL-C： 4.21-4.97 mmol/L） ; severe high LDL-C group （ H3 group, n= 121, LDL-C≥ 4.98 mmol/L）. Pulse wave velocity （PWV） and Ankle- brachial index （ABI） were measured by arteriosclerosis measurement system to evaluate the elasticity. The difference in 4 groups was compared. Results PWV values in H2 and H3 groups were mildly elevated, with statistical difference compared with C and H1 groups whose PWV values were within normal range [H2 group： （1623±115） cm/s,H3 group： （1720±100） cm/s,C group： （1288±103） cm/s,H1 group： （1266±112） cm/s, P〈0.05]. ABI in all the groups was normal with no significant differences. Conclusion Early increased LDL- C may lead to mild reduction of artery elasticity. PWV may be helpful to detect early artery atherosclerosis.

关 键 词：脂蛋白类 LDL 胆固醇 动脉弹性 脉搏波传导速度 踝臂指数 

分 类 号：R543[医药卫生—心血管疾病]