慢性阻塞性肺疾病患者改良BODE评分与传统BODE评分的相关性分析  

Correlation analysis of modified and conventional BODE indices in COPD patients

作　　者：陈瑞[1] 陈荣昌 刘杰[1] 郑劲平[1] 陈炼[2] 

机构地区：[1]广州医学院第一附属医院广州呼吸疾病研究所呼吸疾病国家重点实验室,510120 [2]广东省人民医院门诊部

出　　处：《中华生物医学工程杂志》2010年第3期259-262,共4页Chinese Journal of Biomedical Engineering

基　　金：基金项目：广东省自然科学基金研究团队项目（04205342）

摘　　要：目的研究慢性阻塞性肺疾病（COPD）患者改良BODE评分与传统BODE评分的相关性。方法对2006年9月至2007年3月广州医学院第一附属医院和广东省人民医院呼吸门诊就诊的42例中、重度COPD缓解期患者进行常规肺功能、6min步行距离、MRC呼吸困难评分、体质量指数测量和症状限制递增功率心肺运动试验。改良BODE评分以最大摄氧量（VO2max）或最大摄氧量占预计值百分比（V02maxpred）代替传统BODE评分中6min步行距离。结果6min步行距离与V02max呈中度负相关（r=-0．502，P〈0．01），与V02maxpred呈低度负相关（r=-0．375，P〈O．05）；传统BODE评分分别与W02max和V02maxpred呈中度负相关（r=-0．498，r=-0．556，P〈0．01）；改良BODE评分1[（4．75±2．03）分]和改良BODE评分2[（4．12±2．11）分]分别与传统BODE评分[（3．67±2．01）分]呈高度正相关（r=0．945，r=0．943，P〈O．01）。结论改良BODE评分与传统BODE评分呈高度正相关，且传统BODE评分简便易行，不需要昂贵检查设备，适合临床推广应用。Objective To evaluate the correlation between the values of the modified BODE index and conventional BODE index in COPD patients. Methods Forty- two patients with moderate to severe COPD registered to Respiratory Medicine Clinics of The First Affiliated Hospital of Guangzhou Medical College and Guangdong Provincial People＇ s Hospital between September 2006 and March 2007, underwent routine pulmonary function test, 6- minute walk test （6MWT） , MRC dyspnoea score, body mass index （BMI） and symptom- limited incremental cardiopulmonary exercise testing. Maximal oxygen uptake （VO2max） or percentage predicted value of VO2max （VO2max%pred） was used in modified BODE index as a substitute for 6MWT in conventional BODE index. Results There was a moderately negative correlation between 6MWT and VO2max （r =-0.502, P〈O.01 ） , and a mildly negative correlation between 6MWT and VO2max%pred （r=-0.375, P〈0.05）. The conventional BODE index had a moderately negative correlation with VO2max （r= -0.498, P〈0.01） and VO2max%pred （r =-0.556, P〈0.01）. The modified BODE index value 1 （4.75±2.03, r = 0.945, P〈0.01 ） and value 2 （4.12±2.11, r = 0.943, P〈0.01 ） showed highly positive correlations with conventional BODE index. Conclusion The excellent positive correlation between modified BODE index and the conventional BODE index as well as the easy-to-use nature of conventional BODE index warrants its widespread use in clinical practices.

关 键 词：肺疾病 阻塞性 运动试验 呼吸困难 身体耐力 BODE评分 

分 类 号：R563.9[医药卫生—呼吸系统]