健康成年男性视觉性相关刺激脑部反应的fMRI研究  

Brain Hemodynamic Responses to Visual Sex-related Stimulation：An fMRI Study on Healthy Adult Males

作　　者：李玮[1] 王亚蓉[1] 李强[1] 朱佳[1] 杨伟川[1] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《实用放射学杂志》2010年第11期1543-1548,共6页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目（30870685）;陕西省科学技术发展研究项目（2008k12-02）.

摘　　要：目的 研究健康成年男性在视觉性相关刺激下诱发的性渴求和性觉醒反应与大脑激活模式间的关系.方法 12名健康成年男性分别在GE 3.0T扫描仪中进行任务设计的功能扫描,试验刺激采用组块设计,观看与性线索相关的图片和中性图片,数据用SPM5和SPSS13.0处理,获得渴求程度变化及大脑激活图.结果 （1）视觉性相关图片可以成功诱发被试性渴求感（t=11.94,P〈0.001）;（2）当暴露于性相关线索时,大脑有多个区域被激活（P〈0.001,〉10连续显示体素）,主要包括4部分,视觉区、运动调节区和躯体感觉区（枕、顶、颞叶、小脑、中央后回）;边缘结构（下丘脑,海马,杏仁核、尾状核、壳核）;旁边缘区（扣带回,屏状核）;相关皮层（颞下回,枕叶皮质）.结论 人类性渴求以及性觉醒的神经机制复杂,涉及到大脑的认知、情感、动机和自主神经功能,了解相关的脑区将有助于性功能障碍的诊断治疗和康复.Objective To investigate the correlation between brain activation pattern and the sexual desire and sexual arousal induced by visual sex--related stimulation. Methods 12 male healthy adults accepted the EPI scan while viewing sex--related pictures and neutral pictures presented in a block design paradigm at GE 3.0 T scanner. The scores of subjects＇ self--reported sexual craving and the fMRI （functional magnetic resonance imaging ） data were collected and processed by SPSS13.0 and SPM5 . Finally the brain activation maps were achieved. Results （ 1 ）The visual sex--related picture induced the subjects＇ sexual desire successfully（t = 11.94, P〈0. 001）; （2）There were several brain areas activated when subjects exposed to visual sex--related cue compared with neutral cue （P〈0. 001 ,〉10 continuous shown voxels）. The activated regions belonged to 4 parts, respectively they were：（1）human visual cortex, motor modulation cortex and somatosensory cortex （occipital--parietal--temporal region, cerebellum, posteentral gyrus）, （2） limbic structures （hypothatamus , bippoeampus, amygdale, caudate, putamen）, （3） paralimbic areas （cingulate cortex, claustrum）, and （4） the associative cortex （inferior temporal gyrus, occipital cortex）. Conclusion The cerebral mechanisms of male sexual desire and sexual arousal involved in cognitive, emotional, motivational and autonomic neural networks. These findings would shed light on the diagnosis, therapy and possible rehabilitation of sexual dysfunction.

关 键 词：脑 视觉 刺激 性觉醒 功能磁共振成像 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]