前列腺素E1治疗终末期慢性肾衰竭患者的临床疗效  

Clinical study of prostaglandin-E_1(PGE_1) on the treatment for end-stage renal failure

作　　者：衷敬华[1] 张积仁[2] 刘瑞林[1] 袁申平[1] 吴翔[1] 王勇[1] 

机构地区：[1]南方医科大学附属珠江医院 [2]赣州市赣南医学院第一附属医院,江西赣州341000

出　　处：《中国老年学杂志》2010年第22期3235-3237,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金(30471928);广东省自然科学基金(07005203)

摘　　要：目的评价应用前列腺素E1(PGE1)治疗终末期慢性肾衰竭(ESRF)的临床疗效。方法 22例终末期慢性肾衰竭(ESRF)老年患者,分为两组,对照组10例,根据病情常规用药、控制血压、纠正贫血、酸中毒、电解质紊乱等。实验组12例,在未使用组基础上加用PGE1200μg加入10%葡萄糖液500 ml中静脉滴注,1次/d,用药3个疗程,随访3个月,观察两组的临床症状、实验室检查、病死率等相关指标。结果 实验组水肿、腰酸乏力、尿量、食欲、皮肤瘙痒等症状改善程度均比对照组明显。实验组尿素氮(BUN)、血肌酐(Scr)、内生肌酐清除率(Ccr)、尿蛋白等高于对照组,差异有显著性(P<0.05)。实验组死亡率25%,对照组死亡率50%,两组比较差异显著(P<0.05)。结论应用PGE1能减缓慢性肾功能不全的进程,改善肾功能,降低终末期慢性肾衰竭的病死率,改善预后。Objective To investigate the effect of prostaglandin-E1（PGE1） on the treatment for end-stage renal failure（ESRF）.Methods 22 patients with ESRF were chosen and divided into groups with and without PGE1 treatment.Patients in both groups were given basic treatment.PGE1 was added into group with PGE1 treatment.Patients of both groups were followed up for 3 months.Blood urea nitrogen（BUN）,serum creatinine（Scr）,endogenous creatinine clearance rate（Ccr）,haemoglobin（Hb）,albumin,urine protein and urine volume before and after the treatment were observed.Results Patients′ clinical symptoms were obviously ameliorated in with PGE1 treatment group,and BUN,Scr,fatality rate and urine protein were decreased,Ccr was increased（P〈0.05,P〈0.01）.Conclusions PGE1 has significant effect on the treatment for ESRF.

关 键 词：前列腺素E1 终末期慢性肾衰竭 

分 类 号：R692.5[医药卫生—泌尿科学]