重症肌无力患者抑郁、焦虑、失眠发生率及其相关因素分析  

Study of incidence and correlation factors of depression, anxiety and insomnia in patients with myasthenia gravis

作　　者：邱力[1] 冯慧宇[1] 黄鑫[1] 莫蓉[1] 欧昶毅[1] 罗传铭[1] 李言[1] 刘卫彬[1] 

机构地区：[1]广州中山大学附属第一医院神经内科,510080

出　　处：《中华医学杂志》2010年第45期3176-3179,共4页National Medical Journal of China

基　　金：基金项目：国家自然科学基金（200830870850）;广东省科技专项基金（20078016002039）

摘　　要：目的 探讨重症肌无力（MG）患者抑郁、焦虑、失眠的发生率及其相关因素.方法 采用汉密顿焦虑量表、汉密顿抑郁量表、匹兹堡睡眠质量指数量表、MG日常生活量表及自制一般情况调查表对2009年11月至2010年7月在中山大学附属第一医院神经科门诊就诊的161例MG患者进行调查,并用逐步Logistic回归统计方法对各相关因素进行分析.结果 本组患者中抑郁发生率58.3%,焦虑发生率45.3%,失眠发生率39.1%.对MG影响较大的相关因素有：并发抑郁是年龄、肢体乏力、日常生活量表评分 并发失眠是年龄、呼吸困难、患胸腺瘤、术后1个月情况、糖皮质激素用量 并发焦虑的相关因素是分享经验.结论 MG患者半数左右存在不同程度的情感障碍,其相关因素可为防治MG并发情感障碍提供参考依据.Objective To investigate the incidence rate and correlation factors of depression,anxiety and insomnia in patients with myasthenia gravis （MG）.Methods A total of 161 MG patients were assessed and graded with HAMD,HAMA,PSQI,QMG,ADL and a self-made scale chart.And the correlation factors were analyzed by Logistic stepwise regression.Results The prevalence of depression,anxiety and insomnia was 58.3%,45.3% and 39.1% respectively.The correlation factors with significant influences on MG were as follows： depression with age,physical weakness,score of QMG,life scale grading anxiety with experience-sharing insomnia age,dyspnea,thymoma,physical status at 1 month post-operation,prednisone dose and score of QMG.Conclusion Nearly one half of the MG patients suffer from affective disorders to different degrees.And an analysis of its correlation factors provides references to prevent and treat the affective disorders concurrently with MG.

关 键 词：重症肌无力 抑郁症 焦虑 入睡和睡眠障碍 

分 类 号：R686[医药卫生—骨科学]