1-(Z)-[2-(三芳基锡基)乙烯基]环戊醇及其衍生物的合成及生物活性  

Syntheses and Biological Activities of 1(Z) (Triarylstannyl)vinyl] Cyclopentanols and Their Derivatives

作　　者：岳淑美[1] 戴慧聪[1] 潘华德 

机构地区：[1]东北师范大学化学系

出　　处：《应用化学》1999年第2期9-13,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金

摘　　要：合成了１４种新的（Ｚ）［２（三芳基锡基）乙烯基］环戊醇类有机锡化合物，通过元素分析、ＩＲ、１ＨＮＭＲ对所合成的化合物进行了表征，结果表明（Ｚ）［２（三芳基锡基）乙烯基］环戊醇类有机锡化合物中乙烯式双键为顺式构型，分子内羟基与锡原子发生配位，形成五元螯合环．生物活性测定结果表明，二卤化物在抗癌，免疫及受体作用等方面具有优良的活性．Fourteen 1(Z cyclopentanols were prepared by the reaction of triaryltin hydrids with 1ethynylcyclopentanol. The reaction of compounds 1 and 2 with ICI, Br2, and I2 gave six organotin halides, respectively. The compounds were characterized by elemental analysis, IR, 1H NMR and some of them showed antitumor and immune activities.

关 键 词：环戊醇 合成 生物活性 有机锡 

分 类 号：O627.42[理学—有机化学]