枢丹不同给药时间对全子宫切除术后不良反应的观察  

Taking time of ondansetron on untoward effect in patients after panhysterectomy

作　　者：徐林依 

机构地区：[1]江苏省南通第一人民医院麻醉科,江苏南通226001

出　　处：《家庭医药（医药论坛）》2010年第10期742-744,共3页

摘　　要：目的:本文旨在探讨枢丹不同给药时间对妇科腹腔镜全子宫切除术后预防PONV效应的观察。方法:80例ASAI～2级妇科腹腔镜全子宫手术病人随机分成四组,每组20例,第Ⅰ组(对照组)术前、术后给予生理盐水5毫升。第Ⅱ组(术前枢丹组)于麻醉诱导前予枢丹4毫克(用生理盐水稀释至5毫升)。第Ⅲ组(手术结束即刻组)于手术结束即刻静脉予枢丹4毫克(用生理盐水稀释至5毫升)。第Ⅳ组(全麻抜管后30分钟组)全麻抜管30分钟后静脉予枢丹4毫克(用生理盐水稀释至5毫升)。观察患者术后24小时内恶心呕吐的发作情况。结果:如若手术时间过短(<2h)或过长(>4h)或改进腹,此病例被剔除,再行选择。确保每组20例病例。第二组与对照组恶心、呕吐发生率相比均降低,但无明显差异(P>0.05)。第Ⅲ、Ⅳ组与对照组恶心、呕吐发生率相比均明显降低,有明显差异(P<0.05)。第Ⅳ组与第Ⅲ组恶心、呕吐发生率相比均降低,但无明显差异(P>0.05)。结论:枢丹的给药时机应选择在手术结束后。Object：To compare the effects of injecting ondansertron at different time on preventing postoperative nausea and vomiting（PONV）for patients undergone gynaecological laparoscopic total hysterectomy.Methods：randomly divide 80 patients who have undergone gynaecological laparoscopic total hysterectomy into 4 groups,20 patients each.Patients in groupⅠ.（control group）were injected 5ml physiological saline solution each before induction and after operation.Patients in groupⅡ（preoperative ondansertron group）were injected 4mg ondansertron before induction.patients in groupⅢ（postoperative ondansertron group）were injected 4mg ondansertron after operation.Patients in groupⅣ（30minutes after extubation ondansertron group）were injected 4mg ondansertron 30minutes after extubation（The ondansertron was diluted with physiological saline solution to 5mg）.Record the postoperative nausea and vomiting 24 hours after operation.Results：If the operation period was too short（2h）or too long（4h）or the operation was turned to be laparotomy,it was not be included in the study.The postoperative nausea and vomiting rates in groupⅡ were lower than group I,with no obvious difference though（P0.05）.The postoperative nausea and vomiting rates in groupⅢ and in guoupⅣ were significantly lower than groupⅠ（P0.05）.The postoperative nausea and vomiting rates in groupⅣ were lower than groupⅢ with no significant difference（P0.05）.Conclutions The injection of ondansertron to prevent nausea and vomting should be conducted at the end of operation.

关 键 词：枢丹 妇科腹腔镜手术 

分 类 号：R722.12[医药卫生—儿科]