分子内Pinner/Dimroth重排串联合成吡啶并嘧啶酮化合物的设计研究  

Ono-pot Synthesis of pyridopyrimidinones via Intramolecular Pinner/Dimroth Rearrangement

作　　者：张奇[1] 杨留攀[1] 王春霞[1] 李加荣[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081

出　　处：《合成化学》2010年第B09期170-174,共5页Chinese Journal of Synthetic Chemistry

摘　　要：以芳香醛、丙二腈和相应的酮为原料一锅法合成了5个邻氨基吡啶氰1a-1e。在强碱催化下,将制得的中间体1与环己酮加热回流成功合成了5个个未见文献报道的吡啶并嘧啶酮类似物2a-2e。目标化合物2的结构经IR,1H NMR,13C NMR,ESI和元素分析确证。O-aminopyridinenitriles 1a-1e was prepared by one-pot condensation from aromatic aldehyde,malononitrile and corresponding ketone.In the presence of sodium methoxide,reaction of O-aminopyridinenitriles（1） with cyclohexanone under reflux gave the new pyridopyrimidinones analogues 2a-2e which were not reported before.Their structures were confirmed by IR,1H NMR,13C NMR,and ESI spectra and elemental analysis.

关 键 词：邻氨基吡啶氰 环己酮 PDF反应 吡啶并嘧啶酮 

分 类 号：TQ457.29[化学工程—农药化工]