2-乙酰氨基-4-叔丁基苯酚的合成工艺研究  

Study on Progress in Synthesizing 2-Acetylamino-4-Butylphenol

作　　者：尹志刚[1] 费宗雷[1] 李占才[1] 钱恒玉[1] 张春霞[1] 

机构地区：[1]郑州轻工业学院河南省表界面科学重点实验室

出　　处：《合成化学》2010年第B09期179-182,共4页Chinese Journal of Synthetic Chemistry

基　　金：河南省杰出青年基金项目(0512001100)

摘　　要：本文以苯酚为初始原料,按照文献方法合成了4-叔丁基苯酚与2-硝基-4-叔丁基苯酚,用5%Pd/C作催化剂,通过催化氢化合成2-氨基-4-对叔丁基苯酚(OB酚),研究了OB酚N-乙酰化工艺条件,发现合成N-乙酰化OB酚的较佳工艺条件为:反应温度30℃,酰化剂用量为OB酚1.05个当量,反应时间8 h,介质pH 6.5;在此工艺条件下,N-乙酰化OB酚收率高达99.2%,选择性98.7%。2-Nitro-4-butylphenol was obtained from 4-butylphenol which can be prepared following reported methods.And then,2-amino-4-butylphenol was syhthesized by hydrogenation over 5% Pd/C.It was found from investigating the acetylation on nitrogen atom.that the optimum conditions of synthesizing 2-acetylamino-4-butylphenol are as follows： acylating agent and its molar ratio to 2-amino-4-butylphenol was 1.05,reaction time was 8h,reaction temperature was 30℃,and pH 6.5.And 2-acetylamino-4-butylphenol can be obtained with the yield of 99.2% and selectivity of 98.7%.

关 键 词：催化氢化 乙酰化 2-乙酰氨基-4-叔丁基苯酚 合成工艺 

分 类 号：TQ463.4[化学工程—制药化工]