荧光素-卟啉的合成及其清除活性氧自由基性质  

Synthesis of a fluorescein-porphyrin hybrid and its scavenging effects on active oxygen free radicals

作　　者：陆家政[1] 郭海伟[1] 黄锦汪[2] 蒋京[1,2] 曾宪栋[1] 臧林泉[1] 

机构地区：[1]广东药学院药科学院,广东广州510006 [2]中山大学化学与化学工程学院,广东广州510275

出　　处：《右江民族医学院学报》2010年第6期828-831,共4页Journal of Youjiang Medical University for Nationalities

基　　金：国家教育部科学技术研究重点项目(208105);广东药学院启动基金项目(43540119)

摘　　要：目的合成一种与醚键相连含自由羧基的荧光素-卟啉二元化合物并研究其体外清除活性氧自由基。方法以元素分析、UV-Vis、IR、1H-NMR和ESI-MS对目标物质进行表征;用分光光度法测定荧光素-卟啉化合物体外清除活性氧自由基的性质。结果合成产物为目标荧光素-卟啉二元化合物,该化合物可有效清除活性氧自由基。结论带活性官能团的荧光素-卟啉化合物可能是一种良好的自由基清除剂。Objective To Synthesis of a porphrin-fluorescein hybrid,and study its scavenging effects on active oxygen species in vitro. Methods Porphrin-fluorescein Hybrid was characterized by UV/Vis,IR,1H-NMR,ESI-MS and elemental analysis.Its scavenging effects on active oxygen species was investigated by the means of spectrophotometry.Results A fluorescein-porphyrin hybrid has been synthesized and characterized.Porphyrin fluorescein hybrid could scavenge active oxygen free radical efficiently.Conclusion The porphyrin fluorescein hybrid is a good free radical scavenger agent in vitro.

关 键 词：荧光素-卟啉 活性氧 自由基清除剂 

分 类 号：R965[医药卫生—药理学]