布洛芬混悬液中布洛芬的质量测定  

Quality Determination of Ibuprofen in Suspension by HPLC

作　　者：仇毅[1] 黄文娴[1] 吴卉[1] 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003

出　　处：《抗感染药学》2010年第4期260-261,共2页Anti-infection Pharmacy

摘　　要：目的:确立布洛芬混悬液中布洛芬质量的高效液相色谱法的测定方法。方法:采用XDB-C184.6mm×150mm为分析柱,乙腈:醋酸-醋酸钠缓冲液(60:40)为流动相,流速1.0mL/min,检测波长263nm,柱温4℃。结果:布洛芬在0～0.1mg/mL范围内,质量浓度(p与峰面积响应值(A)线性关系良好。回归方程:A=1500.7p-0.1882(r=0.9996),平均回收率为100.62%,RSD=0.97%。结论:该法操作简便、准确,可用于布洛芬混悬液中布洛芬质量控制。Objective：To establish a HPLC method for determination of Ibuprofen in suspension.Methods：HPLC analysis was carried out by employing Symetry C18 column and a mixture of acetonitrile and acetic acid buffer（60：40） as mobilephase.The detection wavelength was at 263 nm and flow rate was 1.0 mL/min.Results：The linear regression equation was A=1 500.7 P-.188 2（r=0.999 6）.linear range was 0~0.1 mg/mL,and the average recovery was 100.62%（RSD=0.97%）.Conclusion：This method is accurate and convenient.Itcan be used to determine Ibuprofen in suspension.

关 键 词：布洛芬 混悬液 高效液相色谱法 含质量测定 

分 类 号：R978.69[医药卫生—药品]