ET-1、CRP与PCOS患者血管内皮功能的相关性  

Correlations of ET-1 and CRP with function of blood vessel endothelium of women with PCOS

作　　者：王丽[1] 吕淑兰[1] 曹缵孙[1] 

机构地区：[1]西安交通大学医学院第一附属医院妇幼保健中心,陕西西安710061

出　　处：《中国妇幼健康研究》2010年第6期787-789,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的 通过对多囊卵巢综合征患者和健康妇女血清内皮素-1、C反应蛋白水平的检测对比,分析两者在多囊卵巢综合征患者不同分组中的水平,以期将其作为预测多囊卵巢综合征患者心血管疾病等远期并发症风险的指标.方法 选择在西安交通大学第一附属医院妇产科门诊就诊的多囊卵巢综合征患者68例,同时选择65例同龄健康女性为对照组,所有受试者均记录一般资料,检测血清内皮素-1、C反应蛋白水平及其他相关实验室资料,并进行统计分析.结果 ①对多囊卵巢综合征组的体重、身体质量指数、腰围、臀围、腰臀比、Ferriman-Gallwey评分及痤疮评分较对照组显著升高（t值分别为8.38、7.16、5.58、10.17、11.10、14.40、8.64,均P〈0.01）;②多囊卵巢综合征组的血清内皮素-1、C反应蛋白水平显著高于对照组（t值分别为24.20、7.68,均P〈0.01）;③多囊卵巢综合征患者中肥胖组血清内皮素-1水平较非肥胖组显著升高（t=18.81,P〈0.01）,而C反应蛋白水平无显著性差异;④多囊卵巢综合征患者中胰岛素抵抗组血清内皮素-1、C反应蛋白水平较非胰岛素抵抗组显著升高（t值分别为12.66、7.71,均P〈0.01）.结论 内皮素-1、C反应蛋白可能影响了多囊卵巢综合征患者的血管内皮功能,进而影响其预后和远期并发症的发生,故该病患者应定期检测血清内皮素-1、C反应蛋白水平及糖代谢情况,对伴胰岛素抵抗和/或肥胖者更应密切关注血管内皮功能.Objective To detect serum levels of endothelin-1 （ ET-1 ） and C reactive protein （CRP） of PCOS and healthy women in order to determine whether ET-1 and CRP can be used as indexes to predict risks of cardiovascular diseases and other long-term complications. Methods 68 women with polycystic ovary syndrome（PCOS） treated in outpatient of department of gynecology and obstetrics in our hospital were selected and 65 healthy women with same age were recruited as controls. General information and other laboratory data of all subjects were recoded and their serum levels of ET-1 and CRP were detected. All data were analyzed statistically. Results ①The body weight, BMI, waist circumference, hip circumference, waist/hip circumference ratio, Ferriman-Gallwey （F-G） score and acne score of women with PCOS were significantly higher than normal women （t = 8.38, 7.16, 5.58, 10. 17, 11. 10, 14.40, 8.64 respectively, all P 〈 0.01 ） ; ②The serum levels of ET-1 and CRP of women in PCOS group were significantly higher than those in the control group（ t = 24.20, 7.68 respectively, both P 〈0.01 ） ; ③The serum level of ET-1 of obese women with PCOS was significantly higher than that of those non- obese women （t = 18.81, P 〈0.01 ）, while in serum level of CRP there was no significant difference between the two subgroups; ④The serum levels of ET-1 and CRP in insulin resistance （IR） PCOS women subgroup were significantly higher than those of POCS women without IR （t = 12.66, 7.71 respectively, both P 〈 0.01 ）. Conclusion This study demonstrates that ET-1 and CRP may influence the function of blood vessel endothelium of women with PCOS, thereby affect prognosis and long-term complications of the patients further. Therefore, the serum levels of ET-1 and CRP and glycometabolism of women with PCOS should be detected regularly. For those women who have IR and/or obesity, more and close attention should be paid to their function of blood vessel endothelium.

关 键 词：内皮素-1 C反应蛋白 多囊卵巢综合征 血管内皮功能 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]