牛黄降压方对自发性高血压大鼠肾小动脉影响的病理形态观察  

Histopathological Observation of Renal Arteriole for Effect of Compound Calculus Bovis Depressurization Formula on Spontaneous Hypertensive Rats

作　　者：柳占彪[1] 马涛[1] 贾晓旭[1] 康立源[1] 张少卓[1] 胡利民[1] 

机构地区：[1]天津中医药大学中医药研究院,天津300193

出　　处：《中国实验方剂学杂志》2010年第17期122-124,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划课题(2007BAI47B04)

摘　　要：目的:观察牛黄降压方对自发性高血压大鼠(SHR)肾小动脉硬化的影响。方法:选14周龄SHR大鼠,用牛黄降压方ig治疗8周,观察大鼠肾小动脉的病理变化。结果:牛黄降压方1.2,0.6,0.3 g·kg-1(生药粉),0.6 g·kg-1(片剂)组与模型组比较,血压均显著降低(P<0.01),出现肾小动脉硬化的例数减少,分别占总动物数的20%,20%,30%,40%(模型组80%),病变血管数量减少,病变程度减轻,病理学评分分别为5,5,7,7分,(模型组20分),经秩和检验(K-S),牛黄降压方高、中治疗组与模型组差异有显著意义(P<0.05)。结论:成年自发性高血压大鼠可继发肾小动脉硬化,牛黄降压方在抗血压升高的同时,对肾小动脉的硬化具有一定的保护作用。Objective： To observe histopathological changes in renal arteriolar sclerosis for effect of Compound Calculus Bovis Depressurization Formula（CCBDF） on spontaneous hypertensive rats（SHR）.Method： SHR of 14-week was used in the study.The rats were treated with CCBDF through intragastric administration for 8 weeks,then histopathological changes in renal arteriole were investigated.Result：Compared with the model group,blood pressure in treated groups[1.2,0.6,0.3 g·kg-1（crude drug powder） and 0.6 g·kg-1（tablet）]were all reduced significantly（P 0.01）;the numbers of SHR renal arteriolar sclerosis were decreased,accounting for 20%,20%,30%,40% of total animal number respectively（model group 80%）;the number of vessels diseased（NVD） was reduced;and the extent of lesion was lessened.The pathological grades of the four treated groups was 5,5,7,7 score respectively（model group 20 score）.Rank sum test（K-S） showed there was significant difference between treated groups（high and middle doses）and model group（P 0.05）.Conclusion： Adult SHR can develop renal arteriolar sclerosis and CCBDF has protective effect on SHR renal arteriolar sclerosis as it reduces their hypertension.

关 键 词：自发性高血压大鼠 牛黄降压方 高血压 肾动脉硬化 病理形态 

分 类 号：R285.5[医药卫生—中药学]