促酰化蛋白水平与胎儿生长发育关系  

Relationship between plasma acylation-stimulating protein and growth and development of fetus

作　　者：郑俊虎 冯维良[1] 郑骆颖 杜文君[1] 林锋 王靖[1] 

机构地区：[1]浙江省瑞安市人民医院妇幼分院新生儿科,325200

出　　处：《中国公共卫生》2010年第12期1523-1525,共3页Chinese Journal of Public Health

基　　金：温州市科技计划项目(Y20080048);瑞安市科技计划项目(20082087)

摘　　要：目的探讨脐血促酰化蛋白(ASP)水平与胎儿生长发育关系。方法选择大于胎龄儿(OGA)、适于胎龄儿(GA)和小于胎龄儿(YGA)各30人,检测脐血、母血和羊水ASP水平,分析脐血ASP与胎儿生长发育各指标、血脂、胰岛素、瘦素和脂联素等的相关性。结果 OGA、GA、YGA的脐血ASP水平分别为(40.6±1.38),(36.7±1.76),(33.8±1.73)mg/L,3组比较差异有统计学意义(F=133.341,P<0.001);3组新生儿血脂各指标水平比较差异均无统计学意义(F≤3.086,P>0.05);脐血ASP水平与新生儿出生体质量、身长、体质指数(BM I)、腰围、腰臀比、胰岛素、瘦素、脐血甘油三酯水平呈正相关(r≥0.653,P<0.001),与脐血脂联素水平呈负相关(r=-0.785,P<0.001),与母血和羊水ASP水平、胎盘重量无关(r=0.064,1.173,-0.236,P>0.05)。结论促酰化蛋白参与胎儿生长发育调节,脐血ASP水平可反映胎儿的生长发育状况。Objective To study the relationship between plasma acylation-stimulating protein（ASP） and growth and development of fetus.Methods Totally 30 infants older than gestational age（OGA）,30 gestational age（GA） infants and 30 infants younger than gestational age（YGA） were enrolled in the study.The relationships between ASP concentration in cord blood and that of maternal blood and amniotic fluid,ASP in cord blood and placental weight,indexes of fetus development,blood fat,insuline,leptin,and serum adiponectin of the pregnant woman were studied.Results The ASP in cord blood of OGA（40.6±1.38 mg/L）was significantly higher than that of in GA（36.7±1.76 mg/L）.The level of ASP in cord blood of GA was significantly higher than that of in YGA（33.8±1.73 mg/L;F=133.341,P0.001）.The blood fat showed no statistical difference among the three groups（F≤3.086,P0.05）.The correlation analysis showed positive correlations between ASP in cord blood and body weight,body length,body mass index,waistline,waist-to-hip ratio,triglyceride in cord blood,insuline,and leptin（r≥0.653,P0.001）.The correlation analysis showed a negative correlation between ASP in cord blood and serum adiponectin（r=-0.785,P0.001）.There was no significant difference in ASP of cord blood and maternal blood or amniotic fluid（r=0.064,1.173,-0.236;P0.05）.There was no significant correlation between cord blood and placental weight（r=-0.236,P0.05）.Conclusion The ASP of cord blood is related to the adjustment of fetal growth.The ASP level can reflect the status of fetal development.

关 键 词：促酰化蛋白 胎儿 血脂 体质指数 脐血 

分 类 号：R715[医药卫生—妇产科学]