慢性血栓栓塞性肺动脉高压治疗策略选择  

Selection of therapeutic strategies for chronic thromboembolic pulmonary hypertension

作　　者：翟振国[1] 王辰[1] 

机构地区：[1]首都医科大学附属北京朝阳医院北京呼吸疾病研究所北京市呼吸与肺循环疾病实验室,北京100020

出　　处：《中国实用内科杂志》2010年第12期1080-1082,共3页Chinese Journal of Practical Internal Medicine

基　　金：国家973项目(2009CB522107);国家自然科学基金重大国际合作项目(30810103904);北京科技新星计划(2007B037)

摘　　要：慢性血栓栓塞性肺动脉高压(CTEPH)是一种严重威胁生命的疾病,临床一次或多次血栓栓塞事件发生或反复发生使肺血管床阻塞,血流阻力增加,肺动脉压力进行性增高,最终导致右心力衰竭。肺动脉血栓内膜切除术(pulmonary thromboendarterectomy)是CTEPH的治疗手段之一,为CTEPH的患者提供了治愈的可能。CTEPH远端肺动脉病变可考虑内科药物治疗。但是何时选择外科手术干预,如何正确选择内科药物治疗,仍需要进一步的研究进行评价。Chronic thromboembolic pulmonary hypertension（CTEPH）is a life-threatening disease characterized by single or recurrent thromboemboli episode in clinic which results in pulmonary vascular obstruction,increased pulmonary vascular resistance and progressive pulmonary hypertension,and subsequently the right-heart failure.Pulmonary thromboendarterectomy is one of the therapies for CTEPH promising for a curative outcome in patients with this disease.Conservative medications may be considered for pulmonary arterial lesion of distal CTEPH.However,further investigations are needed as to when to start surgical intervention and how to choose medical therapies properly.

关 键 词：慢性血栓栓塞性肺动脉高压 肺动脉血栓内膜剥脱术 

分 类 号：R5[医药卫生—内科学]