脂蛋白相关磷脂酶A_2与动脉粥样硬化性脑梗死关系的研究进展  

Progress in the Relationship between Lipoprotein-associated Phospholipase A_2 and Atherosclerotic Cerebral Infarction

作　　者：吴计划[1] 钟萍[2] 

机构地区：[1]蚌埠医学院,安徽蚌埠233030 [2]上海市中西医结合医院神经内科,上海200082

出　　处：《医学综述》2010年第23期3555-3557,共3页Medical Recapitulate

摘　　要：动脉粥样硬化是一种慢性炎症过程,炎性标志物参与了动脉粥样硬化性脑梗死的发生与发展。脂蛋白相关磷脂酶A2(LP-PLA2)是由炎性细胞分泌的一种炎性标志物,可用于动脉粥样硬化性脑梗死的危险分层,其与初次动脉粥样硬化性脑梗死的再次复发存在一定的相关性。LP-PLA2有可能作为脑梗死复发的风险预测标志物,降低其水平有可能作为一种非降脂治疗策略预防脑梗死的复发。Atherosclerosis is the main cause of atherosclerotic cerebral infarction（ACI）,as a chronic inflammation process.The inflammatory markers take part in the formation and development of atherosclerotic cerebral infarction.Lipoprotein-associated phospholipase A2（LP-PLA2）is a specific inflammation marker produced by inflammatory cells.Studies have shown that LP-PLA2 can be used for the risk stratification of atherosclerotic cerebral infarction in recent years.LP-PLA2 is correlated with the risks of atherosclerotic cerebral infarction recurrence.LP-PLA2 may be used as a risk predictor of cerebral infarction recurrence.Reducing the level of LP-PLA2 is likely to be a therapeutic modality to prevent the cerebral infarction recurrence.

关 键 词：脂蛋白相关磷脂酶A2 动脉粥样硬化 脑梗死 复发 

分 类 号：R743.3[医药卫生—神经病学与精神病学]