氨酪酸在反复热性惊厥脑损伤中的作用  

Effects of Aminobutyric Acid on Brain Damage in Recurrent Febrile Seizure

作　　者：郑文静[1] 夏晓玲[1] 

机构地区：[1]昆明医学院第二附属医院儿科,昆明650101

出　　处：《医学综述》2010年第23期3609-3611,共3页Medical Recapitulate

摘　　要：热性惊厥是小儿时期最常见的惊厥性疾病,儿童期患病率3%～4%,约50%的患儿会在今后发热时再次或多次发生热性惊厥。反复热性惊厥过程中,氨酪酸(GABA)作为中枢神经系统重要的抑制性神经递质在海马区有显著改变,并且GABA与气体信号分子一氧化氮、一氧化碳及硫化氢相互调节,平衡兴奋/抑制状态。了解GABA在反复热性惊厥中的变化,能更好地理解其在脑损伤中的作用。Febrile seizure is the most common convulsive disease at childhood,with a morbidity of 3-4%.Half of the sick children will have one or more seizure in cases of recurrent fever.In the process of recurrent febrile seizure,gamma-aminobutyric acid（GABA）,as a inhibitory neurotransmitter,has a significant change in hippocampus,and interacts with other air molecules,such as nitric oxide,carbon monoxide and hydrogen sulfide to balances the excitation and inhibition.Consequently,the better understanding of the change of GABA in recurrent febrile seizure will be beneficial to characterize its effects on brain damage.

关 键 词：反复热性惊厥 氨酪酸 一氧化氮 一氧化碳 硫化氢 

分 类 号：R729[医药卫生—儿科]