米非司酮用于绝经过渡期功能性子宫出血治疗的临床进展  

The Progress of the Role of Mifepristone in Perimenopausal Period-dysfunctional Uterine Bleeding Treatment

作　　者：李惠萍[1] 尚玉敏[1] 

机构地区：[1]天和医院妇产科,天津300050

出　　处：《医学综述》2010年第23期3639-3641,共3页Medical Recapitulate

摘　　要：绝经过渡期功能性子宫出血是由于下丘脑-垂体-卵巢轴功能失调所致。临床表现为月经频发,经血量多,经期延长,贫血及感染等。诊断性刮宫和子宫内膜病理学检查是最可靠的诊断依据。米非司酮既能作用于丘脑,又能直接作用于垂体,亦可作用于卵泡颗粒细胞,促其凋亡。米非司酮可使子宫螺旋动脉萎缩,诱导子宫内膜细胞凋亡,使子宫内膜萎缩。故米非司酮治疗绝经过渡期功能性子宫出血,近期疗效确切,不良反应小。The dysfunctional uterine bleeding during perimenopausal period is caused by the dysfunction of hypothalamus-pituitary gland-ovary axle.The clinical manifestation is polymenorrhea,profuse uterine bleeding,bradymenorrhea,anaemia,infection and so on.It′s diagnosis is mainly according from dilation and curettage,and pathobiological result.Mifepristone will cause the apoptosis of hypothalamus,pituitary gland,or the follicular cell.The shrink of the utero-helicine arteries will induce the apoptosis and atrophy of endometrium with mifepristone.The curative effect is certain,and the adverse reaction is minor with mifepristone in dysfunctional uterine bleeding during perimenopausal period.

关 键 词：米非司酮 功能性子宫出血 绝经过渡期 

分 类 号：R711.52[医药卫生—妇产科学]