益肾解毒通络汤对糖尿病大鼠肿瘤坏死因子-α的影响  

The effect of Yishen Jiedu Tongluo Recipe on tumor necrosis factor-α in diabetic nephropathy rats

作　　者：金英花[1] 南征[2] 

机构地区：[1]广东药学院附属第一医院,广东广州510080 [2]长春中医药大学第一附属医院,吉林长春130021

出　　处：《中国当代医药》2010年第34期17-18,113,共3页China Modern Medicine

摘　　要：目的:观察益肾解毒通络汤对实验性糖尿病肾病的影响。方法:以链脲菌素诱导的糖尿病大鼠为动物模型,经益肾解毒通络汤10ml/kg体重(相当于30g生药/kg)治疗12周后,检测空腹血糖、HbA1C、血脂、血肌酐、尿素氮、24h尿蛋白定量,采用放免法检测血清TNF-α的表达水平。结果:益肾解毒通络汤明显改善DM大鼠的一般状态,降低血糖,改善肝功能、肾功能,减少血清中TNF-α水平。结论:益肾解毒通络汤对实验性DM大鼠肾脏有保护作用,其机制可能与调节糖代谢和脂代谢,改善肾功能,减少尿蛋白排出,降低血清TNF-α水平有关。Objective：To observe the effect of Yishen Jiedu Tongluo Recipe（YSJDTLR） on tumor necrosis factor-α in diabetic nephropathy rats.Methods：The diabetic nephropathy models of rats（n=60） were produced by inducement of Streptozotocin（50 mg/kg）.The blood glucose,glycol-hemoglobin,TC,TG,BUN,SCR,the level of 24 h Urine protein,tumor necrosis factor-α,and Urine protein were measured at 12 weeks after ＂YSJDTLR＂（10 ml/kg） were treated with rats.TNF-α was measured by methods of radioimmunoassay.Results：The blood glucose,glycol-hemoglobin,tumor necrosis factor-α,TC,TG,BUN,SCR and Urine protein were decreased after YSJDTLR（10 ml/kg） treatment compared with the DM group.Conclusion：The study suggests that YSJDTLR has protective effect on DM rats.The mechanisms might related to the regulation of glucose metabolism and lipid metabolism,and the improvement of kidney function,also decrease of TNF-α.

关 键 词：糖尿病肾病 益肾解毒通络汤 肿瘤坏死因子-Α 

分 类 号：R587.2[医药卫生—内分泌]