报告基因显像监测干细胞治疗的研究进展  

Advances of reporter gene imaging monitoring stem cell therapy

作　　者：裴之俊[1] 张永学[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,武汉430002

出　　处：《国际放射医学核医学杂志》2010年第2期73-75,87,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（30830041,30571816,30772208,30970853）

摘　　要：干细胞移植治疗各种组织损伤或退行性疾病是目前国内外研究热点,而对干细胞移植后的活体归巢、分化及功能表达等动态变化却所知甚少,影响了干细胞治疗的进一步发展.报告基因显像是分子影像技术的重要组成部分,通过间接监测转染报告基因的表达,可以动态监测移植干细胞活体内变化过程.该文简述报告基因显像活体监测移植干细胞治疗的最新研究进展和未来发展趋势.Stem cell transplantation in the treatment of various tissue damage or degenerative diseases are research hotspots both at home and abroad. However, ignorance of the homing, differentiation and functional expression of the stem cell in vivo influence the further development of stem cell therapy. As an important component of molecular imaging technology, reporter gene imaging dynamically monitors the change of stem cell in vivo via monitoring the expression of transfected reporter gene. This paper briefly describes the latest research progress and the future development trend of the monitoring of reporter gene imaging in stem cell therapy in vivo.

关 键 词：基因 报告 分子诊断技术 干细胞移植 

分 类 号：R4[医药卫生—临床医学]