特发性中枢性性早熟病因的研究进展  

Etiology of idiopathic central precocious puberty

作　　者：张晓洁[1] 杨培蓉[1] 黄晓东[1] 

机构地区：[1]上海交通大学医学院附儿童医学中心小儿内分泌科,200127

出　　处：《国际内分泌代谢杂志》2010年第6期418-420,423,共4页International Journal of Endocrinology and Metabolism

摘　　要：性发育是青春发育开始直至具有生育能力的一个序贯过程。特发性中枢性性早熟指未发现中枢神经系统器质性病变的性早熟，其确切病因和触发机制尚未完全阐明，受体内外诸多因素影响，如遗传因素、代谢因素、环境因素等。其中遗传因素对青春期启动时间的决定作用占50％～80％，涉及神经内分泌因素（KiSS-1／G蛋白耦联受体54系统、神经递质、生长因子）和染色体异常。现就特发性中枢性性早熟的病因和分子机制方面的研究进展作一综述。Puberty is a transition between childhood and the adult reproductive stage. Idiopathic central precocious puberty has no associated lesion of the central nervous system. The exact triggers have not yet been elucidated. Puberty development is a multifaceted process that is under control of different regulatory mechanisms such as genetic, metabolic and environmental factors. About 50% -80% of the calculated measures of heritability of puberty are of genetic origin. Neuroendocrine factors （ KiSS-1/GPR54 system, neurotransmitters, growth factor） and chromosome abnormality are also involved. Advance in research of etiology of idiopathic central precocious puberty will be reviewed here.

关 键 词：特发性中枢性性早熟 病因学 KISS-1 GPR54 

分 类 号：R725.8[医药卫生—儿科]