β-环糊精聚合物微球包结当归挥发油的研究  

Study on β-cyclodextrin polymeric microspheres of angelica oil

作　　者：李仲谨[1] 韩春鹏[1] 杨威[1] 陈玉苗[1] 丁金浩[1] 田晓静[1] 

机构地区：[1]陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西西安710021

出　　处：《现代化工》2010年第12期40-43,共4页Modern Chemical Industry

基　　金：国家自然科学基金项目(50573046)

摘　　要：以β-环糊精聚合物(β-CDP)微球为原料,采用饱和水溶液法制备当归挥发油β-CDP微球包结物;以挥发油包结率和包结物产率为评价指标,通过L9(34)正交试验设计对制备工艺进行了优化。结果表明:最佳制备工艺条件是挥发油1 mL,β-CDP微球为6 g,包结温度为30℃,包结时间为4 h,水为120 mL;影响因素的大小依次为:包结时间>β-CDP微球与水之比>包结温度>当归挥发油和β-CDP微球投料比。With β-cyclodextrin polymer （β-CDP） microspheres as material, volatile oil β-CDP inclusion microspheres are prepared by saturated aqueous solution method;With volatile oil inclusion rate and the rate of inclusion property as evaluation index, the fabrication process is optimized through L9 （34） orthogonal experimental design. The results show that the best preparation conditions are as follows：l mL of volatile oil ,6 g of/3-CDP microspheres,30℃ of inclusion temperature ,4 hours of inclusion time, 120 mL of water; The importance of influencing factors is in turn： inclusion time 〉β-CDP ratio of the microspheres and water 〉 inclusion temperature 〉 the feed ratio of volatile oil and β- CDP microspheres.

关 键 词：β-环糊精聚合物微球 当归挥发油 回归分析法 方差分析 

分 类 号：TQ461[化学工程—制药化工]