香青兰总黄酮HPMC骨架片释放度的影响因素考察  

Study on Influencing Factors on Release of Dracocephalum Total Flavones from HPMC Matrix Tablets

作　　者：杨秀[1] 邢建国 王新春[1,3] 薛桂蓬 马祖文[1] 任文东[1] 

机构地区：[1]石河子大学药学院,新疆石河子832000 [2]新疆维吾尔自治区药物研究所,乌鲁木齐830004 [3]石河子大学医学院一附院,新疆石河子832008

出　　处：《中国实验方剂学杂志》2010年第18期6-9,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项课题新药创制(2009ZX09103-448)

摘　　要：目的:制备香青兰总黄酮HPMC(羟丙甲纤维素)骨架片,考察主要活性成分田薊苷体外释药的影响因素。方法:以HPMC为缓释骨架材料,采用湿法制粒压片法制备香青兰总黄酮骨架缓释片;测定香青兰总黄酮HPMC骨架片中主成分田薊苷在不同时间点的释放度,通过对体外释放曲线2,6,12 h累积释放度的综合评分K值及释放曲线相似因子f2的综合比较,考察影响田薊苷体外释药的因素。结果:骨架材料HPMC的种类及乳糖和淀粉的比例是影响田薊苷体外释放的主要因素。骨架材料HPMC的用量及粘合剂等因素对田薊苷释放的影响不大。结论:HPMC K15M能有效控制香青兰总黄酮缓释骨架片中主成分的释放。Objective：Total flavones sustained-release tablets of Dracocephalum were prepared and the influencing factors on release of the tilianin of Dracocephalum were studied. Method：The Dracocephalum total flavones sustained-release tablets were compressed after wet granulating the extracts of Dracocephalum total flavones with HPMC. Then, the influencing factors on release of tilianin were investigated by determining release-rate of til- ianin at different time to draw release curve and calculate K value （a kind of index comprehended with cumulative release at 2, 6, 12 h, respectively） and f2 （similar factorof release curve）. Result： The main influencing factors on release-rate of tilianin were the type of HPMC and the ratio of starch to lactose; the amount of HPMC and adhesive were the secondary. Conclusion： The release of tilianin of Saussurea involucrate could be controlled effectively by selecting HPMC K15M as matrices.

关 键 词：香青兰总黄酮 缓释片 释放度 羟丙甲纤维素 

分 类 号：R283.6[医药卫生—中药学]