四消丸的质量标准研究  

Studies on Qualitative and Quantitative Methods of Sixiaowan Pill

作　　者：赖新华[1] 唐丽丽 

机构地区：[1]韶关市粤北医院药剂科,广东韶关512026 [2]韶关市药品检验所,广东韶关512028

出　　处：《中国实验方剂学杂志》2010年第18期68-70,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:建立四消丸的质量标准。方法:采用TLC法对四消丸中大黄、槟榔和香附进行定性鉴别,采用HPLC法测定制剂中大黄素和大黄酚的含量。结果:在薄层色谱中能检出大黄、槟榔和香附;含量测定中大黄素在0.051 3～0.256 5μg浓度范围内呈良好的线性关系(r=0.999 7);大黄酚在0.153 9～0.769 5μg呈良好的线性关系(r=0.999 5)。结论:建立的分析方法简便可行,专属性强,可用于四消丸的质量控制。Objective：To study the qualitative and quantitative methods of Sixiaowan pill. Method：Radix et Rhizoma Rhei, Rhizoma Cyperi, Crataegus pinnatifida and Areca catechu in Sixiaowan pill were identified with the method of TLC. The contents of emodin and chrysophanol were determined with the method of HPLC. Result： For TLC, the spots of four herbal drugs were well separated and without interference. Emodin and chrysophanol were linear in the range of 0. 051 3-0. 256 5μg and 0. 153 9-0. 769 5μg respectively. Conclusion： The methods set up by this study were accurate and easy to perform with the merits of good resolution, specificity and reproducibility. It could effectively control the quality of Sixiaowan pill.

关 键 词：四消丸 薄层色谱法 高效液相色谱法 

分 类 号：R284.1[医药卫生—中药学]