灰关联聚类法评价补中益气汤对大鼠气虚发热的效果  

Evaluation of Effect of Buzhong Yiqi Tang on Rats of Qi-deficiency with Fever by Grey Relational Clustering Method

作　　者：刘瑜彬[1] 王晖[1] 唐晓峰[1] 薛漫清[2] 

机构地区：[1]广东药学院中药学院,广州510006 [2]广东药学院护理学院,广州510006

出　　处：《中国实验方剂学杂志》2010年第18期124-128,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省科技计划项目(2008A060202005);广东药学院中青年骨干教师资助项目

摘　　要：目的:探讨灰关联聚类法在综合评价补中益气汤对大鼠气虚发热的效果中的运用。方法:SD大鼠随机分为正常组、气虚组、气虚发热组、阳性对照组(阿司匹林)、补中益气汤高、中、低剂量组。利用游泳劳损法加限食法制作气虚模型,除正常组、气虚组外,各组ip脂多糖(LPS)建立大鼠气虚发热模型,比较各组测量体温与基础体温差值ΔT、大鼠的体重,运用灰关联聚类法对实验结果进行综合评价。结果:对于治疗大鼠气虚发热的效果,阿司匹林与高剂量的补中益气汤最好,中剂量的补中益气汤与低剂量的补中益气汤次之。结论:灰关联聚类法可客观地、公正地评价补中益气汤对大鼠气虚发热的效果。Objective：To investigate the utilization of grey relational clustering method in evaluating the treatment of Buzhong Yiqi Tang on rats with Qi-deficiency and fever.Method：SD rats were randomly divided into normal group,Qi-deficiency group,Qi-deficiency and fever group,positive control group（aspirin）,high-dose Buzhong Yiqi Tang group,middle-dose Buzhong Yiqi Tang group and low-dose Buzhong Yiqi Tang group.Swimming strain method and dietary restriction method were utilized to establish the rat model of Qi-deficiency and fever by intraperitoneal injection of LPS. The difference △T between rats＇ measuring temperature and BBT of each group was then compared. Finally, using gray relational clustering method a comprehensive evaluation of the experimental results was conducted. Result：As for the treatment on rats with Qi-deficiency and fever, aspirin group and high-dose Buzhong Yiqi Tang group were the best, middle-dose Buzhong Yiqi Tang group and low-dose Buzhong Yiqi Tang group ranked behind. Conclusion：Grey relational clustering method can evaluate the effect of Buzhong Yiqi Tang on rats of Qi-deficiency with fever objectively and fairly.

关 键 词：灰关联聚类法 补中益气汤 气虚发热 

分 类 号：R285.5[医药卫生—中药学]