中药活血利湿方对酒精性肾损害的干预作用  

Intervention of Huoxue Lishi Prescription in Rats Alcoholic Kidney Damage

作　　者：邱皓 吕晓云[2] 刘文 滕玉莲[2] 刘明龙[3] 陶小红 

机构地区：[1]甘肃省第二人民医院,兰州730000 [2]兰州大学,兰州730000 [3]兰州大学第一医院,兰州730000

出　　处：《中国实验方剂学杂志》2010年第18期187-189,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：2010年甘肃省中医药科研立项课题(GZK-2010-27)

摘　　要：目的:研究复方中药活血利湿方(HLP)对酒精灌胃大鼠肾损害的干预作用。方法:Wistar大鼠乙醇灌胃造模,HLP灌胃处理,分别于第4,8,12周末检测大鼠血尿素氮、肌酐水平,以HE染色、透射电镜观察肾脏组织病理改变。结果:随着造模时间的延长,HLP组大鼠血尿素氮、肌酐水平较模型组明显降低(P<0.05和P<0.01);肾小球系膜增殖、间质炎性细胞浸润、肾小管上皮变性、肾小管扩张等病理改变亦较模型组明显减轻。结论:中药活血利湿方对大鼠酒精性肾损害具有良好的干预作用。Objective：To study the effect of Huoxue Lishi prescription （HLP） on rats renal injury induced by alcohol. Method： The animal model of alcoholic renal injury was established with the method of direct intragastric infusion of ethanol and HLP. At the end of 4,8, 12 weeks, the blood ureanitrogen （BUN）, and creatinine（Scr） were measured and the renal pathological changes were observed by HE staining and transmission electron microscope,respectively. Result： In HLP group, BUN and Cr were all decreased （ P 〈 0.05, P 〈 0.01 ） and some pathological changes, such as hyperplasia of mesangium, interstitial infiltration of inflammatory cell, the degeneration of renal tubularepithelial cell and the dilatation of tubule appeared late and were attenuated as time progressed, compared with that of alcohol group （P 〈 0.05）. Conclusion： Huoxue Lishi prescription could inhibit rats renal injury induced by alcohol.

关 键 词：酒精性肾损害 中药 活血利湿方 

分 类 号：R285.5[医药卫生—中药学]