芳环C—H键直接芳基化反应研究进展  

RecentAdvances in Direct Arylation Via C-H Activation of Arenes

作　　者：华晓莹[1] 辛炳炜[2] 

机构地区：[1]青岛科技大学化工学院,青岛266042 [2]德州学院化学系,山东德州253023

出　　处：《德州学院学报》2010年第6期99-105,共7页Journal of Dezhou University

基　　金：山东省自然科学基金(No.ZR2009BM042);第四十六批中国博士后科学基金(No.20090461211)

摘　　要：过渡金属催化的C-H活化反应是当前有机化学极具挑战性的重要研究课题之一,其中芳环C-H直接芳基化反应占有重要地位.近年来人们对此进行了大量研究,并取得了瞩目的研究成果.芳环C-H直接芳基化反应分两大类:芳环C-H与卤代烃的反应以及与金属有机试剂的反应.为提高芳环C-H的反应活性,在芳环上需要引入导向基团,OH、CONR_2、COR、C=N-R以及吡啶、咪唑、噻唑等含氮杂环均为良好的导向基团.研究发现,Ru、Pd配合物是C-H活化反应常用的催化剂,其次是Rh配合物.在本实验室研究工作的基础上,综述了近几年芳环sp^2 C-H直接芳基化反应研究进展.The study of transition-- metal-- catalyzed lenges of modern chemistry. Among these, direct ar the activation of C--H bonds is one of the major chal ylation via the C--H activation of arenes is an useful transformation, which has achieved tremendous development. To date, several different types of transition -- metal-- catalyzed aryt-- aryl bond formation have aryl pseudo-- halides, arylation with tetraary been reported,involving arylation with aryl halides or or arylboronates （arylboronic acid esters）. OH,CoNR2, COR,C=N--R and some heterocycles can be employed as directing groups in irder to improve the Palladium and ruthenium catalysts are currently used most frequently, closely followed by rhodium activity. comple xes. A review of some recent advances in the area of arylation via direct C-H activation of arenes is pres ented.

关 键 词：C—H活化反应 芳环C—H活化 芳基化反应 导向基团 研究进展 

分 类 号：O621.3[理学—有机化学]