机构地区:[1]Department of Respiratory Diseases,Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China [2]Department of Oncology ,Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China [3]Department of Hematology,Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China [4]Department of Oncology, Jiangsu Cancer Hospital, Nanjing,Jiangsu 210009, China [5]Department of Oncology, 81th Hospital of People's Liberation Army, Nanjing, Jiangsu 210034, China [6]State Key Laboratory of Bioelectronics, Southeast University,Nanjing, Jiangsu 210096, China
出 处:《Chinese Medical Journal》2010年第23期3427-3432,共6页中华医学杂志(英文版)
基 金:This work was supported by the grants from the Prophase Force-Study Program of the Jiangsu Province Natural Science Foundation (No. BK2005203), the Medical Science Technology Research "Eleventh Five-Year" Program of the People's Liberation Army (No. 06MAlll), and the Focal Project of Nanjing Medical Technology Development (No. ZKX05030).
摘 要:Background Platinum-based chemotherapeutics are the most common regimens for advanced non-small-cell lung cancer (NSCLC) patients, and genetic factors are thought to represent important determinants of drug efficacy. We prospectively assessed the status of the XPC Ala499Val and Lys939GIn gene polymorphisms and investigated whether these SNPs can predict the response to cisplatin/carboplatin-based regimens in advanced NSCLC patients in a Chinese population.Methods The treatment outcomes of 96 advanced NSCLC patients who were treated with platinum-based chemotherapy were evaluated. The polymorphic status of xeroderma pigmentosum group C (XPC) gene was genotyped by the 3-D polyacrylamide gel-based DNA microarray method.Results The distributions of XPC Lys939GIn genotypes differed significantly between the response group (complete +partial responses) and the non-response group (stable + progressive disease; P=0.022). The heterozygous A/C genotype carriers had a poorer response rate than the wild A/A genotype carriers in stage Ⅲ (OR, 0.074; 95% CI,0.008-0.704; P=0.023). The XPC Ala499Val polymorphisms were not associated with response to platinum-based chemotherapy.Conclusion Polymorphisms of the XPC gene, Lys939GIn, may be a predictive marker of treatment response for advanced NSCLC patients in stage Ⅲ.Background Platinum-based chemotherapeutics are the most common regimens for advanced non-small-cell lung cancer (NSCLC) patients, and genetic factors are thought to represent important determinants of drug efficacy. We prospectively assessed the status of the XPC Ala499Val and Lys939GIn gene polymorphisms and investigated whether these SNPs can predict the response to cisplatin/carboplatin-based regimens in advanced NSCLC patients in a Chinese population.Methods The treatment outcomes of 96 advanced NSCLC patients who were treated with platinum-based chemotherapy were evaluated. The polymorphic status of xeroderma pigmentosum group C (XPC) gene was genotyped by the 3-D polyacrylamide gel-based DNA microarray method.Results The distributions of XPC Lys939GIn genotypes differed significantly between the response group (complete +partial responses) and the non-response group (stable + progressive disease; P=0.022). The heterozygous A/C genotype carriers had a poorer response rate than the wild A/A genotype carriers in stage Ⅲ (OR, 0.074; 95% CI,0.008-0.704; P=0.023). The XPC Ala499Val polymorphisms were not associated with response to platinum-based chemotherapy.Conclusion Polymorphisms of the XPC gene, Lys939GIn, may be a predictive marker of treatment response for advanced NSCLC patients in stage Ⅲ.
关 键 词:single nucleotide polymorphism gene-chip/microarray xeroderma pigmentosum group C non-small-cell lung cancer CHEMOTHERAPY
分 类 号:S852.43[农业科学—基础兽医学] Q346.5[农业科学—兽医学]
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