酶联免疫吸附法测定他克莫司血药浓度  

Determination of concentration of tacrolimus by ELISA

作　　者：苏琴 郭亚东[2] 吴双凤[2] 宾婕[2] 帅莉[2] 许彬[2] 

机构地区：[1]昆明法医院组织配型中心,云南昆明650031 [2]昆明医学院药学院,云南昆明650031

出　　处：《中国民族民间医药》2010年第23期54-54,57,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:为使用他克莫司的肾移植患者制定有效的治疗窗浓度。方法:用酶联免疫吸附法测定全血他克莫司谷浓度,并对他克莫司谷浓度的监测结果进行分析。结果:他克莫司治疗窗浓度范围:第1个月内为11.09±5.22ng/mL,2～3月为8.98±3.80ng/mL,4～6个月为8.08±4.07ng/mL,7～12月为6.65±3.22ng/mL,>12个月为5.11±2.55ng/mL。结论:常规监测他克莫司全血谷浓度,按推荐治疗窗调整给药方案,即能达到满意的免疫抑制治疗效果,又能减少他克莫司的毒副作用。Objective： To find out the valid therapeutic window concentration of tacrolimus in Chinese kidney transplant recipients.Methods： Tacrolimus valley point concentrations in the whole blood were measured by ELISA.The levels of tacrolimus in samples were described and studied.Results： The blood tacrolimus trough level was 11.09±5.22ng/mL within the first month,8.98±3.80ng/mL from 2nd to 3rd month,8.08±4.07ng/mL from 4th to 6th month,6.65±3.22ng/mL from 7th to 12th and 5.11±2.55ng/mL after 12th month.Conclusions： It is necessary to routinely monitor blood concentrations of tacrolimus.The satisfying therapeutic effects,less rejection and toxic effects will be obtained if dosage regimens will be individualized according to optimal therapeutic window.

关 键 词：他克莫司 血药浓度 酶联免疫吸附法 

分 类 号：R969.3[医药卫生—药理学]