新疆维吾尔族、汉族育龄妇女多囊卵巢综合征临床特征分析  

Clinical characteristics of Han and Uygur child-bearing patients with polycystic ovary syndrome in Xinjiang

作　　者：林琳[1] 米娜[2] 丁岩[1] 王婧[1] 刘婷[1] 

机构地区：[1]新疆医科大学第一附属医院妇科,乌鲁木齐市830054 [2]塔城市人民医院妇科,新疆维吾尔自治区830000

出　　处：《中华实用诊断与治疗杂志》2010年第12期1154-1157,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金资助项目(30960407)

摘　　要：目的:探讨新疆维吾尔族(维族)、汉族育龄妇女多囊卵巢综合征患者的临床特征。方法:问卷调查新疆部分地区2 867名育龄妇女,对检出的217例(汉族126例、维族91例)多囊卵巢综合征患者与同期166名正常妇女(对照组)比较其临床特征及激素水平。结果:(1)多囊卵巢综合征总体以及维族、汉族发生率分别为7.569%,8.675%,6.931%,以≤35岁育龄妇女多见。(2)与对照组相比多囊卵巢综合征组肥胖、多毛、痤疮及黑棘皮症的发生均高于对照组(P<0.05),体质量指数、腰臀比高于对照组(P<0.05)。(3)多囊卵巢综合征组及对照组组内比较,维族高雄激素表现较汉族多见(P<0.05),尤其是多毛评分。(4)多囊卵巢综合征组肥胖患者的雌二醇、黄体生成素、黄体生成素/促卵泡素、睾酮、游离雄激素指数较非肥胖者高(P<0.05),而性激素结合球蛋白、胰岛素敏感指数、低密度脂蛋白低于非肥胖患者(P<0.05)。结论:≤35岁育龄妇女是多囊卵巢综合征的主要群体;且维族在高雄激素、多毛方面表现较汉族突出,可能与种族差异有关;育龄期多囊卵巢综合征肥胖患者存在糖代谢和脂肪代谢方面的改变,应重视其胰岛素抵抗及肥胖对疾病发生、发展的影响。Objective To approach the clinical characteristics of Han and Uygur child-bearing patients with polycystic ovary syndrome in Xinjiang.Methods A total of 2 867 child-bearing aged women were investigated with questionnaire in Xinjiang,in which 217 patients with polycystic ovary syndrome（126 Han patients and 91 Uygur patients） were compared the clinical characteristics and the hormone level with 166 healthy controls.Results（1） The total incidence of polycystic ovary syndrome was 7.569%,and the incidences were 8.675% and 6.931% in Uygur and Han patients.Most polycystic ovary syndrome cases occurred in the women younger than 35 years old.（2） The body mass index,waist-to-hip ratio and the incidences of obesity,hairness,acne and acanthosis nigricans were higher in patients with polycystic ovary syndrome than those in controls（P0.05）.（3） There were more cases of hyperandrogenism in Uygur patients than that in Han patients in both groups（P0.05）.（4） The levels of estradiol,luteinizing hormone,luteinizing hormone/folicle stimulating hormone,testosterone,free androgen index were higher（P0.05）,and the levels of sex hormonebinding globulin,insulin sensitivity index and low density lipoprotein were lower（P0.05） in obese patients than those in non-obese patients in polycystic ovary syndrome group.Conclusion The main age of polycystic ovary syndrome distributes in the women younger than 35 years old.The incidences of hyperandrogenism and hariness are higher in Uygur than those in Han patients,which may be related to racial differences.The obese patients with polycystic ovary syndrome are usually complicated with glycometabolic disorder and lipometabolic disorder.The influence of insulin resistance and obesity on polycystic ovary syndrome should be focused on.

关 键 词：多囊卵巢综合征 汉族 维吾尔族 

分 类 号：R711.75[医药卫生—妇产科学]