移植肾穿刺组织病理学检查及临床分析  

Histopathological study and clinical analysis of renal allograft biopsies

作　　者：韩永[1] 黄海燕[1] 许晓光[1] 蔡明[1] 王强[1] 石炳毅[1] 

机构地区：[1]解放军第309医院全军器官移植中心研究室,北京市100091

出　　处：《中华实用诊断与治疗杂志》2010年第12期1173-1174,1178,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家科技支撑计划基金(2008BAI60B04)

摘　　要：目的:探讨移植肾术后组织病理穿刺活检对临床诊断与治疗的指导意义。方法:肾移植术后患者82例,行常规穿刺组织病理活检,依据Banff 05标准进行病理分型,通过移植肾的病理状态明确诊断,并进行相应临床治疗,观察治疗效果。结果:81例诊断明确,1例因获取组织量较少难以诊断。82例患者中31例肾功能延迟恢复,其中28例移植肾功能恢复,3例移植肾功能至今未恢复;51例血肌酐水平升高者经治疗后44例血肌酐水平呈不同程度下降,3例慢性移植肾功能不全,4例血肌酐稳定于较高水平。结论:移植肾穿刺组织病理活检安全、可靠,对患者及移植肾无不良影响,对肾移植术后移植肾功能不全的辅助诊断和治疗有重要意义。Objective To evaluate the significance of renal allograft biopsies in clinical diagnosis and treatment.Methods Eighty-two patients undergoing renal transplantation received biopsy and were typed according to Banff＇05 standard.Based on the pathological findings,diagnoses were made and corresponding treatment were employed.The effect was observed and analyzed.Results Eighty-one patients got clear diagnosis and one did not get certain diagnosis due to the lack of material.Renal function was recovered in 28 of 31 patients with delayed graft function and the other 3 patients remained graft dysfunction till now.The level of creatinine decreased in 44 of 51 patients with originally elevated creatinine,3 patients suffered from chronic renal allograft dysfunction,and 4 patients remained a high level of creatinine.Conclusion Renal allograft biopsy is safe,reliable and has no adverse reaction.Biopsy is a valuable approach and plays an important role in the diagnosis and treatment of renal dysfunction after transplantation.

关 键 词：肾移植 活组织检查 病理学 

分 类 号：R446.8[医药卫生—诊断学]