犬颅脑爆震伤战地早期救治的疗效观察  

Early treatment of dogs with craniocerebral explosive injury under the field situation

作　　者：张广林[1] 高国栋[2] 王本瀚[1] 贺世明[2] 高立[2] 于嘉[2] 高波[2] 

机构地区：[1]解放军153医院神经外科,河南郑州450042 [2]第四军医大学唐都医院神经外科

出　　处：《西北国防医学杂志》2010年第6期407-409,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：全军"十一五"军事医学重点基金资助项目(05XJM005)

摘　　要：目的:观察野战环境战地早期救治对颅脑爆震伤实验犬的救治效果。方法:杂种雄性犬30只,随机分为:对照组(n=6),外伤组(n=12)及治疗组(n=12),制作成颅脑爆震伤模型,治疗组运用大剂量青霉素、甘露醇等进行治疗,观察每一组呼吸、心率、血压、颅内压、生存时间的变化。结果:动物伤后两模型组均出现呼吸、心率减慢、血压降低、颅内压升高,与伤前比较有非常显著差异(P<0.01),经药物治疗后治疗组与外伤组有显著差异(P<0.05);生存时间为治疗组(138.6±8.0h),外伤组(96.5±3.0h),两组有非常显著差异(P<0.01)。结论:早期积极有效的治疗能改善颅脑爆震伤实验犬呼吸、心率、血压、颅内压、生存时间等生命指标,提高颅脑爆震伤犬的救治效果。Objective： To observe the effects of early treatment on dogs with craniocerebral explosive injury under the field situation. Methods： Thirty mongrel male dogs were randomly divided into control group （ n = 6） , injury group （ n = 12） and treatment group （ n = 12） . The injury group and treatment group were established into models of craniocerebral explosive injury. Respiratory frequency（ R） ,heart rate（ HR） ,blood pressure（ BP） , intracranial pressure （ ICP） ,and the survival time were observed in each group. Results： Compared with pretherapy,the index levels of R,HR,BP in both model groups were decreased significantly after cerebral explosive injury （ P 0. 05） ,however,ICP were increased （ P 0. 01） . The index levels were relieved significantly in the treatment group as compared with that of the injury group （ P 0. 05） . The survival time of the treatment group （ 138. 6 ±8. 0 ） h was significantly longer than that of injury group （ 96. 5 ± 3. 0 ） h （ P 0. 01） . Conclusion： Early proper treatment for craniocerebral explosive injury in dogs can relieve the index levels of R,HR,BP,ICP and prolong the survival time under the field situation.

关 键 词：颅脑损伤 爆震伤 早期救治 犬 

分 类 号：R651.15[医药卫生—外科学]