生物膜与人工关节假体感染关系研究进展  

PROGRESS OF RELATIONSHIP BETWEEN BIOFILM AND PROSTHETIC JOINT INFECTION

作　　者：毛彦杰[1] 沈灏[1] 蒋垚[1] 

机构地区：[1]上海交通大学附属第六人民医院骨科,上海200233

出　　处：《中国修复重建外科杂志》2010年第12期1463-1468,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30772182)~~

摘　　要：目的综述生物膜(biofilm,BF)在关节假体感染(prosthetic joint infection,PJI)中的特点、诊断、预防以及治疗。方法查阅近年BF与PJI的相关文献,对BF在PJI中的作用以及诊断和防治进行回顾及综合分析。结果PJI是人工关节置换的严重并发症。基础研究表明其发生的重要原因之一是细菌与关节假体等界面黏附后,通过一系列调控机制,形成BF,从而导致PJI的发生。近年来针对BF相关PJI的病原学、诊断、治疗和预防等方面均有了新的研究进展,研究表明BF与PJI关系密切。结论 BF与PJI的发生、发展密切相关,研究BF对PJI的诊断、治疗和预防有指导意义。Objective To summarize the effect of biofilm （BF） on the occurrence of prosthetic joint infection （PJI）. Methods The domestic and abroad original literature in recent years about the relationship between BF and PJI wasreviewed. Results Infection is a critical complication for prosthetic joint replacement. Basic research showes one of the reasons for PJI is BF. After adherence of the bacteria to the surface of prosthetic joint, BF forms through a series of regulation and control system. And it lead to the occurrence of PJI. Recently a lot of progress have been made in the research fields of BF related PJI, which have covered aetiology, diagnosis, treatment, and prevention. Different studies show that BF has close relationship with PJI. Conclusion BF is proved to have close relationship with PJI. It is important on clinical significances to diagnose, treat, and prevent PJI.

关 键 词：人工关节置换术 生物膜 感染 诊断 治疗 预防 

分 类 号：R687.42[医药卫生—骨科学] R619.3[医药卫生—外科学]