可降解椎间融合器的研究进展  

CURRENT DEVELOPMENT OF RESEARCH OF BIODEGRADABLE INTERBODY FUSION CAGE

作　　者：周春光[1] 宋跃明[1] 刘浩[1] 刘立岷[1] 李涛[1] 龚全[1] 曾建成[1] 孔清泉[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2010年第12期1500-1505,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家科技支撑项目(2007BAE13B04)~~

摘　　要：目的对可降解椎间融合器(Cage)的基础研究及临床应用进展进行综述。方法查阅近年来国内外可降解Cage的相关文献,总结可降解Cage的基础研究及临床应用方面的最新进展。结果基础研究显示,可降解Cage刚度较金属Cage低,可有效促进椎间融合;随着融合的进行,Cage不断降解,但降解速度与融合的发生尚不能达到完美匹配,而且关于降解产物引起的组织反应情况尚有争议。临床应用研究显示,可降解Cage促进椎间融合及维持椎间高度的疗效确切,近期疗效优良,但尚缺乏远期随访结果的支持。结论可降解Cage可有效促进椎间融合。Objective To summarize the basic research and the clinical application of biodegradable interbody fusion Cage. Methods Recent literature concerning biodegradable interbody fusion Cage at home and abroad was extensively reviewed, and current developments of the basic research and the clinical application of biodegradable interbody fusion Cage were investigated. Results Basic research showes that the stiffness of biodegradable interbody fusion Cage is lower than that of metallic Cage, so it can enhance interbody fusion. As interbody fusion proceeded, biodegradable interbody fusion Cage degrades constantly, but the speed of degradation can not keep in parallel with that of fusion. In addition, the tissue response to degradation products is controversy. Clinical application showes that the biodegradable interbody fusion Cage can enhance interbody fusion and maintain disc space height. The short term results are good, however, the long term results need further observation. Conclusion Biodegradable interbody fusion Cage can effectively enhance interbody fusion.

关 键 词：可降解椎间融合器 基础研究 临床应用 

分 类 号：R687.3[医药卫生—骨科学]