中药功能靶点的研究  

Functional targets of Chinese herbal medicine

作　　者：肖斌[1] 王耘[1] 

机构地区：[1]北京中医药大学中药信息工程研究中心,北京100102

出　　处：《中西医结合学报》2010年第12期1190-1194,共5页Journal of Chinese Integrative Medicine

基　　金：国家自然科学基金资助项目(No.30973946)

摘　　要：化学成分-靶点作用关系是在分子层面对中药作用机制的阐释,没能有效结合中医对"人"是功能性认识的特点,同时也难以体现中药整体作用的特色。本文在借鉴西药作用靶点思想的基础上,提出中药功能靶点的研究。通过对2005版《中华人民共和国药典》第一部中所有中药功效术语的整理,得到135个功能靶点。以功能靶点与作用方式作为网络的节点,两者之间的关系作为边构建了中药功能靶点作用网络,并结合四君子汤、麻黄汤对功能靶点及其作用网络的应用进行了探讨。本文对中药功能靶点的研究,紧密结合了中药整体作用的特点,有助于在整体层面阐释中药的作用机制,为中药方剂配伍理论的研究提供了理论依据,为中药复方的设计与优化奠定了理论基础。In order to elucidate the mechanisms of Chinese herbal medicine, much work has been done based on chemical constituent-target in the molecular system. It cannot comply with the holistic efficacy of Chinese herbal medicine. Thus, the authors of this paper proposed to study the functional target adopted from Western medicine. The data of Chinese herbal function were collected from 2005 edition of The People＇s Republic of China Pharmacopoeia. A total of 135 functional targets were found, and a network about functional target and mode of action was built combined with Sijunzi Decoction medicine, will not only be helpful to studying the theory of Chinese The authors also explored the applications of functional target and the network and Mahuang Decoction. The results, reflecting the feature of Chinese herbal to elucidate the holistic mechanisms of Chinese herbal medicine, but also beneficial formulas and developing new formulas.

关 键 词：中药 功能靶点 机制 

分 类 号：R285[医药卫生—中药学]