支撑引流管在胆肠吻合中置放反应的实验研究  

An experimental study on place reaction of support drainage tube in cholecystojejunostomy

作　　者：范作升 孙仕林 李杰[4] 邱昌城 赵宏伟 高涛 王升 张波 李开富 张言敏 

机构地区：[1]高密市人民医院肝胆外科,山东261500 [2]高密市人民医院麻醉科,山东261500 [3]高密市人民医院病理科,山东261500 [4]山东省千佛山医院肝胆外科 [5]高密市市立医院普外科

出　　处：《中华肝胆外科杂志》2010年第11期845-847,共3页Chinese Journal of Hepatobiliary Surgery

基　　金：山东省科技厅医学研究基金立项课题（2001BB1BGB1）

摘　　要：目的 研究支撑引流管在胆肠吻合中的置放反应及其病理改变.方法 将8头实验猪随机分为两组,分别实施置管与不置管的胆肠和胆管吻合各2头.喂养3个月后宰杀取标本做病理对照检验.结果 置管组大体解剖显示吻合口炎性增生、管壁硬化增生、管腔挛缩狭窄、有结石形成;病理切片镜下显示胆管黏膜间质中淋巴细胞、浆细胞等慢性炎性细胞浸润,黏膜下大量纤维组织增生.未置管组大体解剖和病理切片仅见轻微炎性改变,且无管腔狭窄.结论 放在体内的异物支撑引流管,不仅不能防止狭窄形成,反而可刺激促进炎性增生、组织硬化和管腔狭窄形成.Objective To investigate the place reaction of support drainage tube in cholecystojejunostomy and its pathological changes.Methods Eight pigs were randomized into 2 groups.The tube-placing cholecystojeunostomy（n=2）or choledochocholedochostomy（n=2）and non-tube-placing cholecystojejunostomy（n=2）or choledochocholedochostomy（n=2）were performed respectively.All the 8 pigs were sarcrificed 3 months after the operation for pathological examination.Results Gross anatomy catheter group showed anastomotic inflammatory hyperplasia, wall hardening hyperplasia,luminal narrow contracture and stone formation.Microscopic biopsy showed bile duct mucosa in interstitial lymphocytes, plasma cells and other chronic inflammatory cell infiltration, a large number of fibrous tissue hyperplasia.However, these features were not found in pigs without placing the tube.Conclusion The tube can not prevent the stenosis.It might promote the formation of stricture since it can stimulate inflammatory hyperplasia and tissue hardening.

关 键 词：胆肠吻合术 支撑管 实验研究 

分 类 号：R686[医药卫生—骨科学]