无叶假木贼的化学成分研究(英文)  

Two new phenolic glycosides from the stems of Clematis parviloba

作　　者：杨燕[1] 李卫林[2] 巩婷[1] 王洪庆[1] 陈若芸[1] 

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,中草药物质基础与资源利用教育部重点实验室,北京100050 [2]新乡医学院药学院,河南新乡453003

出　　处：《药学学报》2010年第12期1523-1526,共4页Acta Pharmaceutica Sinica

基　　金：Project supported by the Special Foundation for the Major Project of the National Science and Technolgy,China(No.2009ZX09311-004)

摘　　要：为了研究无叶假木贼中的化学成分,采用硅胶、Sephadex LH-20、RP-C18等色谱方法分离纯化,从无叶假木贼的95%乙醇提取物中分离到6个化合物,通过核磁共振谱、质谱等波谱分析手段鉴定化合物结构。其中包括1个新化合物:p-acetyl-phenol 1-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside(1)和5个已知化合物:piceine(2)、isorhamnetin(3)、quercetin(4)、rutin(5)和isorhamnetin-3-rutinoside(6)。化合物2–6均为首次从无叶假木贼中分离得到。To study the chemical constituents of the stems of Clematis parviloba,six compounds were isolated from a 95% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel,ODS,Sephadex LH-20,and semi-preparative HPLC.Two new phenolic glycosides,2-（（E）-3-carboxybut-2-en-yl）-4-hydroxy-3-methyl-phenyl-O-β-D-glucopyranoside（1） and 4＇-hydroxy-phenol-β-D-[6-O-（4＇＇-hydroxy-3＇＇,5＇＇-dimethoxy-benzoate）] glucopyranoside（2） were isolated,together with a known phenolic glycoside,4＇-hydroxy-3＇-methoxy-phenol-β-D-[6-O-（4＇＇-hydroxy-3＇＇,5＇＇-dimethoxy-benzoate）] glucopyranoside（3） as well as three known megastigmane glycosides,linarionoside A（4）,linarionoside C（5）,and staphylionoside K（6）.Their structures were determined on the basis of spectroscopic analysis and chemical evidence.Among them,compounds 1 and 2 were named as clemaparvilosides A（1） and B（2）,respectively,and compounds 3 ？ 6 were obtained from Clematis genus for the first time.

关 键 词：假木贼属 无叶假木贼 p-acetyl-phenol1-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside 

分 类 号：R284.1[医药卫生—中药学]